Research in this field is carried out in Precision NeuroOncology & NeuroVascular Disease Modeling and Translational Neurobiology & Disease Modeling.
Precision NeuroOncology & NeuroVascular Disease Modeling Group
Neuro-Oncological diseases are among the deadliest form of cancer. These diseases include brain and spinal cord neoplasms, including astrocytomas, gliomas, glioblastoma multiforme, ependymoma, and brain stem tumors. Brain metastasis is one of the lethal causes of cancer-related mortality, even outnumbers the primary tumor in the central nervous system (CNS). At the same time, glioblastoma is the most frequent tumor in the brain and is aggressive among all human cancers. Current therapies have significant ramifications, including disruption of brain vasculature and neurodegeneration. We intend to restore these tumors' Neuroplasticity and Regenerative capability using the Precision medicine-based combination therapy approach. A proteomic-based molecular and computational analysis is being developed for novel biomarker identification, which is highly beneficial in deciphering the signaling mechanism. The future calls for exploring more techniques to create personalized anti-cancer therapies to achieve the greater goal of human welfare.
People: Dr. Seema Sehrawat
Translational Neurobiology and Disease Modeling Group
Our group is surveying the human brain for regulatory proteins that resolve the plasticity in phenotypic preferences of microglial cells during the allostatic events across all the human developmental stages. We also study inflammatory cascades in microglia triggered by menacing pathogens such as Plasmodium or Leishmania through neurological disease modeling. Simultaneously, using Stem Cell Technology, we are trying to harvest breakthrough information about the metabolic protein signatures vital for specifying neuronal fate and propagation of various neurological deficiency states within the human brain.
People: Dr. Soumya Pati