Faculty at School of Natural Sciences

Rajan Vyas

Rajan Vyas

Assistant Professor


Contact Information

Structure based drug designing using Protein X-ray crystallography.

Ph.D, Panjab University

09/10 - 03/12

National Institute of Immunology, Postdoctoral Fellow , New Delhi

04/12 - 12/14

The Ohio State University, Columbus, Ohio, Postdoctoral Fellow , US

01/15 - 03/17

Case Western Reserve University, Cleveland, Ohio, Postdoctoral Fellow , US

03/18 - 02/20

Central University of Punjab, Bathinda, Ramalingaswami Fellow (Assistant Professor) , Punjab

2018 - 2023 Selected as Ramalingaswami Re-entry Fellow (2018-2023) by Department of Biotechnology, India. 2007 Availed Deutscher Akademischer Austausch Dienst" (DAAD) fellowship (June 1 - November 30, 2007) sponsored by German Academic Exchange Service to work in European Molecular Biology Laboratory (EMBL-Hamburg), Germany.

  • Bhavya Jha*, Rajan Vyas*, Jaya Bhushan, Devinder Sehgal and Bichitra Kumar Biswal (2019). Structural insights into substrate specificity of SP_0149, the substrate binding protein of a methionine ABC transporter from Streptococcus pneumonia. Acta Crystallogr. Section F75, 520-528. Impact Factor: 1.199 (* equal author).
  • Soumili Chatterjee, Rajan Vyas, Sreevatsa Chalamalasetti, Indra Sahu, Jérôme Clatot, Xiaoping Wan, Gary Lorigan, Isabelle Deschênes, and Sudha Chakrapani, (2018). The Voltage-Gated Sodium Channel Pore exhibits Conformational Flexibility during Slow Inactivation. Journal of General Physiology, 150(9):1333-1347. Impact Factor: 4.788.
  • Rajan Vyas, Andrew J. Reed, Austin T. Raper, Walter J. Zahurancik, Petra C. Wallenmeyer and Zucai Suo. (2017). Structural basis for the D-stereoselectivity of human DNA polymerase β. Nucleic Acid Research, 45(10):6228-6237. Impact Factor: 10.162.
  • Reed, Andrew*; Vyas, Rajan*; Raper, Austin and Suo, Zucai (2017). Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase. J. Am. Chem. Soc. 139 (1), 465–471 (* - equal author). Impact Factor: 13.858.
  • Xing Guo, XiaoYan Sun, Di Hu, Ya-Juan Wang, Hisashi Fujioka, Rajan Vyas, Sudha Chakrapani, Amit Umesh Joshi, Yu Luo, Daria Mochly-Rosen and Xin Qi. (2016). VCP recruitment to mitochondria by mutant Huntingtin causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nature Communication. 7:12646. Impact Factor: 12.124.
  • Nazia Nasir, Avishek Anant, Rajan Vyas, Bichitra Kumar Biswal. (2016). Crystal structures of Mycobacterium tuberculosis HspAT and ArAT reveal structural basis of their distinct substrate specificities. Sci Rep., 6: 18880. Impact Factor:4.259
  • Vyas, R., Efthimiopoulos, G., Tokarsky, E.J., Malik, C.K., Basu, A.K., and Suo, Z. (2015). Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA polymerase. J. Am. Chem. Soc. 137 (37), 12131-12142. (Highlighted in F1000Prime), Impact Factor:13.858
  • Vyas, Rajan; Reed, Andrew; Tokarsky, E. John; Suo, Zucai. (2015). Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography. Journal of the American Chemical Society, 137(15):5225-30. (Highlighted in F1000Prime and Ohio State University Press release and April 26th, 2016 edition of APS Science), Impact Factor:13.858

 

NA

Invited speaker at Bioinformatics & Chemical Biology webinar series organized by the Department of Computational Sciences at Central University of Punjab, Bathinda, Punjab, on 13th Nov 2020.

  • Structural and functional characterization of Suf operon enzymes in Mycobacterium tuberculosis (M.tb) – Department of Biotechnology, India – 32.5 Lakhs grant.
  • Project recommended by the DBT STAG committee (Under Financial Concurrence) "Structural and functional characterization of human CHST11 and CHST13 sulfotransferases involved in the regulation of Metastasis and Chemosensitivity of human Hepatocellular Carcinoma"- Department of Biotechnology, India – Total of 71.65 Lakhs
  • PI: Dr. Rajan Vyas, Shiv Nadar University, Greater Noida, U.P.
  • Co-PI: Dr. Malkhey Verma, Banaras Hindu University, Varanasi, U.P.

NA

NA