Principal Investigator: Dr. Prasun Kumar Roy

Funding Agency: La Fondation Dassault Systèmes

Objective of the Project:

The project is about developing a new neurostimulation protocol for young children (including new-borns) - children that are the victims of brain trauma or new-borns who underwent birth asphyxia.

Construction, validation and implementation of 3D Targeted Neuro-Rehabilitation Physiotherapy

3D Focusing of neurostimulation impulses on damaged brain region (with 3D Printed applicator)

Bioinformatics Formulation to enhance neurostimulation efficacy, using Neuroprotective drugs.

Scope of the Project

• 3-D modelling / Simulation-based therapy planning system for the critical lifesaving sector

• Damaged brain regions are locally activated, with 3D non-invasive neurostimulation pulsing.

• Optimization of location of stimulation lead on scalp so that maximal neural fibre connectivity from lead to damaged tissue is established.

• Development of process to facilitate personalized electromagnetic stimulation therapy through personalised 3D-printed head cap to hold the electrodes, and personalized Finite Element Models of the children’s brains modelled using 3D digital modelling and simulation.

• • Affordable Optimized Physiotherapy Cap for Electro-stimulation, further Enhancing Stimulation Effect by Neuroprotective Drug

• Selection of drug combinations for further augmenting the efficiency of Neurostimulation.

• Validate by Clinical Trial Simulator platform for paediatric patients (with collaborating Neurologists).

Deliverables of the Project

• Stereo Neuro-Rehab Stimulation Platform for Treating Children with Brain Injury.

• 3-D Spatial Maps of Cerebral Conduction Networks, showing Abnormality due to Brain Injury.

• Bioinformatics Formulation for additionally enhancing Neurostimulation performance using Neuroprotective drugs.

• Therapy Planning Protocol for Childhood Cerebral Ischaemia and Stroke.