Faculty at School of Natural Sciences

Sumeet Pal Singh
Associate Professor
School of Natural Sciences
Contact Information
- Email: [email protected]
- Regeneration and plasticity in liver
- Adaptation to metabolic stress such as starvation
- Mechanisms of alcoholic liver & pancreas injury
- B.Tech., Biological Sciences and Bioengineering, IIT Kanpur, India (2004–2008)
- Ph.D, Cell and Developmental Biology, Duke University, USA (2008–2013). Advisor: Dr. Kenneth D. Poss
- Assistant Professor (Tenured), IRIBHM, Université Libre de Bruxelles, Belgium (2022–2026)
- Research Group Leader, IRIBHM, Université Libre de Bruxelles, Belgium (2019–2022)
- Postdoctoral Fellow, CRTD, Dresden, Germany (2014–2019)
- Postdoctoral Fellow, Max Planck Institute CBG, Dresden, Germany (2013–2014)
- EFSD/Lilly Young Investigator Research Award (2018–2019)
- 10x Genomics Best Abstract Award (2020)
- CRTD Best Poster Award (2019)
- DZD Conference Presentation Award (2016)
- Best Talk Awards, Duke University (2012)
- Summer Internship Award, JNCASR (2007)
- Academic Excellence, IIT Kanpur (2004, 2005)
- Mandat d’impulsion scientifique - mobilité Ulysse (MISU) Fellowship, FNRS
- Multiple FNRS Research Credits (PDR, CDR)
- Invited speaker at numerous international conferences (Europe, India, USA)
- Media and public engagement via Science Slam, Pint of Science, and podcasts
- International Society for Regenerative Biology (ISRB)
- European Association for the Study of the Liver (EASL)
- European Zebrafish Society (EZS)
- Indian Society of Developmental Biologists (InSDB)
(Full List Available on https://sumeetpalsingh.github.io/)
- Eski SE, Mi J, Pozo-Morales M, Hovhannisyan GG, Perazzolo C, Manco R, Ez-Zammoury I, Barbhaya D, Lefort A, Libert F, Marini F, Gurzov EN, Andersson O, Singh SP. Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish. Nature Communications: June 06, 2025; doi:10.1038/s41467-025-60334-y 2025.
- Pozo-Morales M*, Cobham AE*, Centola C, McKinney MC, Liu P, Perazzolo C, Lefort A, Libert F, Bai H, Rohner N, Singh SP§.
*Equal contribution, §Co-Corresponding Author. Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity. Life Science Alliance: March 11, 2024; doi:10.26508/lsa.202302458. - Pozo Morales M, Garteizgogeascoa I, Perazzolo C, Singh SP. In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology: March 01, 2023; doi:10.1002/hep.32663.
- Singh SP*, Chawla P*, Hnatiuk A, Kamel M, Silva LD, Spanjard B, Eski SE, Janjuha S, Olivares P, Kayisoglu O, Rost F, Blasche J, Krankel A, Petzold A, Kurth T, Reinhardt S, Junker JP, Ninov N. *Equal contribution. A single-cell atlas of de novo beta-cell regeneration reveals the contribution of hybrid beta/delta cells to diabetes recovery in zebrafish. Development: January 28, 2022; doi:10.1242/dev.199853.
- Romitti M*, Eski SE*, Fonseca BF, Singh SP§, Costagliola S§. *Equal contribution. §Co-Corresponding Author. Single-cell trajectory inference guided enhancement of thyroid maturation in vitro using TGF-beta inhibition. Frontiers in Endocrinology: May 31, 2021; doi:10.3389/fendo.2021.657195.
- Gillotay P, Shankar MP, Haerlingen B, Eski SE, Pozo-Morales M, Garteizgogeascoa I, Reinhardt S, Kraenkel A, Blaesche J, Petzold A, Ninov N, Kesavan G, Lange C, Brand M, Detours V, Costagliola S, Singh SP§. §Co-Corresponding Author. Single-cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland. EMBO Reports: November 06, 2020; doi:10.15252/embr.202050612.
- Singh SP, Janjuha S, Chaudhuri S, Reinhardt S, Dietz S, Eugster A, Bilgin H, Korkmaz S, Zararsiz G, Ninov N, Reid JE. §Corresponding Author. Machine learning based classification of cells into chronological stages using single-cell transcriptomics. Scientific Reports: November 21, 2018; doi:10.1038/s41598-018-35218-5.
- Janjuha S*, Singh SP*, Tsakmaki A, Gharavy SNM, Murawala P, Konantz J, Birke S, Hodson DJ, Rutter GA, Bewick GA, Ninov N. *Equal contribution. Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. eLife: April 06, 2018; doi:10.7554/eLife.32965.
- Singh SP, Janjuha S, Hartmann T, Kayisoglu O, Konantz J, Birke S, Murawala P, Alfar EAA, Murata K, Eugster A, Tsuji N, Morrissey ER, Brand M, Ninov N. Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nature Communications: September 22, 2017; doi:10.1038/s41467-017-00461-3.
- Singh SP, Holdway JE, Poss KD. Regeneration of amputated zebrafish fin rays from de novo osteoblasts. Developmental Cell: Apr 17, 2012; doi:10.1016/j.devcel.2012.03.006
Selected Presentations (2020–2025)
- Cell Plasticity during Liver Regeneration
- 7th European Zebrafish PI Meeting, Paris, France, 2025
- iBMB Ulm, Germany, 2024
- Swiss Zebrafish Meeting, Fribourg, 2024
- IIT Kanpur and IIT Delhi, India, 2023
- IREC Woluwé, Belgium, 2023
- Mechanisms of Starvation Resistance
- Biology Dept., KU Leuven, Belgium, 2022
- IIT Kanpur, India, 2023
- Pint of Science, Belgium, 2020
- Single-cell Endocrinology
- NYU Abu Dhabi, 2021
- University of Wisconsin–Madison, USA, 2021
- Chair / Organizer Roles
- Co-organiser: FNRS Metabolism Contact Group, 2024
- Co-chair: Metabolism and Endocrinology, EZPI Meeting, 2022
- Co-host: Belgian Society of Physiology and Pharmacology, 2021