Faculty at School of Natural Sciences

Ajoy Kapat

Ajoy Kapat

Associate Professor

School of Natural Sciences


Contact Information

  • Chemistry of metalloradicals and modern radical chemistry.
  • Asymmetric Catalysis (organocatalysis, transition metal catalysis & synergistic catalysis)
  • Biomimetic synthesis of biologically active natural products utilizing cascade reactions.
  • Insight-driven development of chemical transformations utilizing computational studies and experimental techniques (mechanistic study of homogeneous catalysis).

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Period Degree Institution Location
09/2007 – 08/2011 Ph.D. in Organic Chemistry University of Bern Switzerland
07/2004 – 07/2006 M.Sc in Chemistry Indian Institute of Technology Madras Chennai, Tamil Nadu, India
08/2001 – 07/2004 B.Sc in Chemistry (Honours), First Class University of Calcutta West Bengal, India

07/19-ongoing
Assistant Professor, Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Delhi-NCR

04/19-06/19
Visiting Research Scientist, Institute of Organic Chemistry, RWTH Aachen University, Germany

11/14-03/19
Postdoctoral Research Fellow, Institute of Organic Chemistry, RWTH Aachen University, Germany

05/14-10/14
Research Associate-I, Organic Chemistry Section, Indian Association for the Cultivation of Science, India

08/12-01/14
Postdoctoral Research Fellow, Frick Chemistry Laboratory, Princeton University, USA

09/11-03/12
Assistant-I, Department of Chemistry and Biochemistry, University of Bern, Switzerland

2024, International Travel Support (ITS) Scheme (ITS/2024/002192)

2022, Special Call-SERB Research Grant (SCP/2022/000168; 62 Lacks)

2022, Special Call-SERB Research Grant (SCP/2022/000168; 62 Lacks)

2020, Start-up SERB Research Grant (SRG/2020/000606; 26 Lacks)

2019, Research Grant from Shiv Nadar University

2016, Molecular Science & Engineering Travel Grant from RWTH Aachen University

2016, Best poster presentation award sponsored by European Journal of Inorganic Chemistry

2014-2016, Post-Doctoral Fellowship from RWTH Aachen University

2012-2014, Swiss National Science Foundation Post-Doctoral Fellowship

2010, 2nd Best poster presentation award, Swiss Chemical Society fall meeting, ETH Zurich

2010, SCNAT/SCS Chemistry Travel Award

2007-2009, ESKAS Scholarship from Swiss Federal Commission

2005, Award of Merit-cum-Means Scholarship from IITM

17) “Efficient Access of Heterocycles Utilising Inherent Carbodicationic Reactivity of Ynone” A. Ahmad, K.Indu, S. A. Siddiqui, L. Gupta, K. D. Dubey*, A. Kapat* Chem. Eur. J. 2025, 31, e202501082.

16) “The Role of the Carbonyl Group in C−C Triple Bond Cleavage of Ynones via Grob-Type Fragmentation Under Acidic Conditions” A. Ahmad, S. A. Siddiqui, P. Tyagi, L. K. Gupta, K. D. Dubey*, A. Kapat*,J. Org. Chem. 2025, 90, 10, 3580-3589.

15) “Regioselective Synthesis of Tetrahydrocarbazole Core of Akuammiline Alkaloids via Palladium-Catalyzed Intramolecular Arylation Reaction” N. M. Rao, A. Shelke, P. B. Singh, A. Ahmad, A. Kapat* J. Org. Chem. 2024, 89, 4461-4466.

14) “Design and Synthesis of Co-Initiators via Base-Catalysed Sequential Conjugate Addition: Application in Photoinduced Radical Polymerisation Reaction” A. Ahmad, S. A. Siddiqui, G. Mittal, N. Sukumar*,D. Dubey*, A. Kapat*, Chem. Eur. J. 2023, 29, e202301844.

13) “Studies Directed towards the Synthesis of the Acridone Family of Natural Products: Total Synthesis of  Acronycines and Atalaphyllidines” T Mandal, S Karmakar, A Kapat, J Dash* ACS Omega 2021, 6, 27062.

12) “Stereoselective and Stereospecific Triflate Mediated Intramolecular Schmidt Reaction: Easy Access to Alkaloid Skeletons” P. Renaud*; L. Gnägi; R. Arnold, F. Giornal, H. Jangra, A. Kapat, E. Nyfeler, R. M.Schärer; H. Zipse*, Angew. Chem. Int. Ed. 2021, 18, 10179.

11)“Stereochemical Control of the Triflate Mediated Intramolecular Schmidt Reaction” L. Gnagi, F. Giornal, H. Jangra, A. Kapat, Nyfeler, H. Zipse*, R. B. Scharer, P. Renaud*, ChemRxiv, 2020

Before joining SNIoE

10)“Synthesis of E-olefins by intramolecular radical relocation” A. Kapat, T. Sperger, S. Guven, and F. Schoenebeck* Science 2019, 363, 391.

Highlighted in Chemistry World: https://www.chemistryworld.com › news › 3010084.article)

9)“Potassium tertiary butoxide mediated direct alkyne addition to Isatine” K. Dhara, A. Kapat, Ghosh, T. And J. Dash* Synthesis 2016, 48,4260.

(Qualified for the competition for the best paper award in Synthesis)

8)“Factors that control C-C cleavage versus C-H bond hydroxylations in copper-catalyzed oxidations of ketones with O2” A. S.-K. Tsang§, A. Kapat§, F. Schoenebeck* J. Am. Chem. Soc. 2016, 138, 518.

(§ASKT and AK contributed equally).

(Most accessed paper in December 2016) (Highlighted in ChemInform 2016 47 29)

7) “Transition-metal free hydration of nitriles using potassium tert-butoxide under anhydrous condition” G.Midya, A. Kapat, S. Maiti, J. Dash* J. Org. Chem. 2015, 80, 4148.

(Highlighted in http://www.organic-chemistry.org/synthesis/C2O/amides.shtm

http://www.organic-chemistry.org/abstracts/lit4/898.shtm)

6) “Unexpected conversion of alkyl azides to alkyl iodides and of aryl azides to N-tert-butyl anilines”, J. Maury, L.Feray*, M. P. Bertrand*, A. Kapat, P. Renaud*, Tetrahedron 2012, 68, 9606.

5) “Radical azidation reactions and their application in the synthesis of alkaloids” G. Lapointe, A. Kapat, K.Weidner, and P. Renaud* Pure Appl. Chem. 2012, 84, 1633.

4) “Radical procedure for the efficient formal anti-Markovnikov hydroazidation of alkenes” A. Kapat,A.Konig, F. Montermini and P. Renaud* J. Am. Chem. Soc. 2011, 133, 13890.

3) “Intramolecular Schmidt reaction involving primary azidoalcohols under nonacidic conditions: synthesis of indolizidine (-)-167B”, A. Kapat, E. Nyfeler, G. T. Giuffredi, and P. Renaud*,J.  Am. Chem. Soc. 2009, 131, 17746.

2) “An intramolecular Schmidt reaction strategy for the synthesis of a methyl analogue of Crispine – A”,P. Synthil Kumar, A. Kapat, S. Baskaran*, Tet. Lett. 2008, 49, 1241.

1) “Synthesis of Crispine - A analogues via an intramolecular Schmidt reaction”, A. Kapat, P. Synthil Kumar,S. Baskaran*, Beilstein J. Org. Chem. 2007, 3, 49.

EDITORIAL APPOINTMENTS & REVIEW ACTIVITIES:

  • Editorial Board Member, Scientific Archives of Dental Sciences 2024
  • Certificate of Appreciation from the ACS as a peer reviewer 2024
  • Certificate of Reviewing from Elsevier as a peer reviewer 2024
  • Certificate of Appreciation from the ACS as a peer reviewer 2023                            
  • Certificate of Appreciation from the ACS as a peer reviewer 2022

Not Applicable

Media Coverage of Our Research Work:

Our recent work on photoinduced radical polymerisation involving hydrogen atom transfer reaction and its application to dental restoration and 3D printing has been covered by a leading media house

 

  1. i) https://x.com/thebetterindia/status/1926647042098479120
  2. ii) https://www.indiatoday.in/health/story/3d-printing-your-tooth-how-an-indian-breakthrough-has-changed-dentistry-2623310-2024-10-28

List of Invited Talks:

  • Invited Delegate, India Chem 2024, Ministry of Chemicals & Fertilisers, Department of Chemicals & Pharmaceuticals Government of India (October 2024)
  • Invited Lecture, ICREST 2024, Jamia Islamia University, Delhi  (July 2024)
  • Invited Session Chairperson, Bern-SRC 2024, University of Bern, Switzerland (June 2024)
  • Invited Lecture, OCS-ECR 2024, IIT Jammu  (March 2024)
  • Invited Delegate, ETCS 2024, IIT Kharagpur  (March 2024)
  • Invited Talk: Massachusetts Institute of Technology, USA.
  • Invited Talk: Indian Institute of Science Education and Research, Thiruvananthapuram, India.
  • Invited Talk: Indian Institute of Science Education and Research, Berhampur, India.
  • Invited Talk: Indian Institute of Technology, Palakkad.
  • Invited Talk: Centre of Biomedical Research, Lucknow.
  • Invited Talk: Indian Institute of Technology, Gandhinagar.
  • Invited Talk: Tata Institute of Fundamental Research, Mumbai.
  • Invited Talk: Indian Institute of Technology, Roorkee.
  • Invited Talk: Indian Institute of Technology, Hyderabad.
  • Invited Talk: Vidyasagar University, Department of Chemistry, Midnapore.
  • Invited Talk: Indian Institute of Technology, Kharagpur.
  • Invited Talk: National Institute of Science Education and Research, Bhubaneswar.

List of Poster Presentations:

  • Poster Presentation, Annual IIT Madras Symposium & The First Mid-Year Meeting of the Chemical Research Society of India, Chennai, India.
  • Poster Presentation, 11th Belgian Organic Synthesis Symposium, Ghent, Belgium.
  • Poster presentation, Swiss Chemical Society Fall meeting, University of Zurich, Switzerland.
  • Oral Presentation, First year graduate student symposium, University of Bern, Switzerland.
  • Poster Presentation, Swiss Chemical Society Fall meeting, EPFL Lausanne, Switzerland.
  • Poster Presentation, 45th Euchem Conference on Stereochemistry, Brunnen, Switzerland.
  • Poster Presentation, Euchem Conference on Organic Free Radicals, Bologna, Italy.
  • Poster Presentation, Swiss Chemical Society Fall meeting, ETH Zurich, Switzerland.
  • Poster Presentation: Bioanorganisches Symposium 2016, RWTH Aachen, Germany.
  • Poster Presentation: 21st International Conference on Organic Synthesis, IIT Bombay, India.
  • Poster Presentation: 9th New Year's Symposium 2017, Institute of Organic Chemistry, RWTH Aachen, Germany.

Ongoing:

Project Title: Enantioselective Catalytic Radical Fluorination of Nonactivated C(sp3)-H Bond

PI: Dr. Ajoy Kapat

Co-PI (if any): Not Applicable

Funding Agency: Science and Engineering Research Board (SERB)

Budget: 62,51,863.00 INR

Date of Approval: 04-11-2022          End Date: 03-11-2025

Completed:

Title: Development of Palladium-Catalyzed Triple Cascade for the Synthesis of Tetracyclic Core of Apocynaceae Family of Indole Alkaloids: Combined Experimental & Computational Based Mechanistic Study and Structure Activity Relationship Study

Principal Investigator: Dr. Ajoy Kapat

Host Institute: Department of Chemistry, School of Natural Products, Shiv Nadar University

Scheme: Start-up Research Grant (SRG/2020/000606)

Date of Approval: 17-12-2020          End Date: 17-12-2022

  1. “Nickel-catalysed olefin isomerisation for the preparation of E-alkenes” A. Kapat and F. Schoenebeck* RD-42066 (filed on 21.09.2018). 
  2. "Highly Atom Economical Process for Synthesis of Novel Co-Initiator for Photo-Induced Radical Polymerisation”. A. Ahmad, G. Mittal, A. Kapat* PCT/IN2023/050615
  1. "Dental Composite And Method Thereof Dental Composite And Method of Curing Thereof”. A. Ahmad, G. Mittal, A. Kapat* PCT/IN2023/050616

Not Applicable