The proposed program therefore aims to achieve the understanding of complex mechanisms of epigenetic regulation in various biological processes. This is accomplished using number of different eukaryotic model systems of increasing complexity from Hydra to Arabidopsis to mouse, to gain insights into the evolution of epigenetic regulation. We propose to use zebrafish and mouse model systems to understand epigenetic control of development and diseases. Our major thrust would be to understand the underlying mechanisms at a global level and study multiple pathways rather than focus on individual genes and their regulation. The proposal also includes specific projects to be undertaken in the CoE that are largely hypothesis-driven, but seeking to combine multiple approaches to address specific questions. Finally, we would like to understand the contribution of the epigenetic mechanisms towards diseases such as cancer and metabolic disorders. Different ideas, questions, and models will make it possible to ask big questions at the highest level which is otherwise not feasible. The CoE also aims to identify and exploit opportunities for the generation, protection and licensing of intellectual property of potential commercial value that may be generated during these studies. 

The scientific strategies proposed to be followed in achieving the vision and objectives of the CoE are: 

(i) To develop and implement a co-operative and collaborative framework for the team leader and the other established investigators to bring together their complementary domains of expertise in Genetics, Cell biology, Biochemistry, Molecular Biology, Computational Biology, to formulate and to address key biological questions in Epigenetics especially focused on early development and regeneration. 

(ii) To expand and augment the research capabilities at the university (in terms of both human and material resources) for this purpose including creation of state-of-the-art facilities such as transgenesis and single cell biology; and (iii) To seek opportunities for generation, protection and licensing of intellectual property of potential commercial value, especially in regenerative biology, that may reveal during the course of these studies.