Nanomedicine for Breast Cancer Exosome Carriers With Thermal Agents And Nanothermometer For Effective Therapy And Monitoring

Applications are invited for the post of Junior Research Fellow (JRF) in a SNF funded research project entitled “Nanomedicine for Breast Cancer: Exosome Carriers With Thermal Agents And Nanothermometer For Effective Therapy And Monitoring " Collab0007, under the supervision of  Dr. Animesh Samanta, Associate Professor, Department of Chemistry, School of Natural Sciences, Shiv Nadar Istitution of Eminence Deemed to be University, Gautam Buddha Nagar, U.P. 201314. E-mail: [email protected]

Web: https://chemistry.snu.edu.in/people/faculty/animesh-samanta

Project Synopsis

This research proposal focusses on the development of nanomedicines that integrates organic exosomes and inorganic perovskite nanocrystals for combined thermal therapy, and real-time intracellular temperature monitoring during therapy. The major objectives are:

Objectives

Objective 1a: Synthesis and characterization of NIR dyes and gold nanorods for photothermal therapy.

Objective 1b: Isolation of exosomes from cancer cells and/or development of nanocarriers for efficient delivery.

Objective 2a: Development of magnetic nanoparticles or perovskite nanocrystals for thermal therapy.

Objective 2b: Monitoring intracellular temperature changes through the development of temperature-sensitive sensors.

Objective 3: Loading photothermal agents and temperature sensors into nanocarriers for effective targeted delivery.

Objective 4: Assessing cellular uptake and synergistic effects of both agents to evaluate photothermal therapy and temperature sensing in breast cancer.

Objective 5: Evaluating the therapeutic efficacy of nanomedicine in zebrafish models.

Nature of work

The primary goal is to discover efficient photothermal agents and temperature sensors through design, synthesis, and spectroscopic analysis, along with cellular studies focusing on thermal therapy.

The project comprises three major components:
(i) synthesis,

(ii) development of temperature sensors and photothermal agents, and

(iii) development of nanocarriers (such as exosomes and others) for efficient delivery, cellular imaging, and assays to evaluate cell death during thermal therapy.

Essential and Desirable Qualifications

• The candidate should have a Master’s degree (with a minimum of 55% marks or equivalent grade) in Chemistry/Solid State Physics from a UGC-recognized University.
• The candidate should have good analytical skills.
• Familiarity with either organic synthesis or cell culture will be preferred.
• Understanding of organic material characterization techniques is desirable.
• Candidates with DST-INSPIRE/CSIR/UGC-NET/GATE are encouraged to apply.

Number of positions: One

Duration of the Project: 30 Months

Fellowship

As per SNF fund approved budget, fellowship is consolidate INR 37,000/- p.m. for JRF. Eligible and interested candidates should submit their application with a complete CV (having personal details, academic qualifications, research experience, publications, name, affiliation and email address of two referees), the copies of marksheets/testimonials/certificates and other relevant documents as PDF attachment.

Last date of Application: 25^th September 2025.

Short-listed candidates may be requested to appear for an online interview.

About the Chemistry Department

Chemistry education at SNU provides a link between the fundamental principles governing the nature of the universe and the science of life, and spans learning towards traditional as well as a variety of interdisciplinary courses.

The department is committed to pursue research on fundamental and applied problems by addressing scientific inquiry of both faculty and student investigators for the development of research & innovation in frontiers areas of multidisciplinary domain - a significant value addition to the industry - academia collaboration, a platform for real-world applications.

Department’s research motto has been to work on diversified areas encompassing the breadth and depth of the chemical sciences in both compelling and interesting problems and that too at various interfaces. This realization is possible with advances in collaborative approach between theory, experiments and methodology at domestic and international levels.

All chemistry labs are equipped with fume-hoods, Schlenk lines, eyewash stations and safety showers. Lab facilities include advanced analytical instruments such as Flash Chromatography, Gas Chromatography with MS, Gel Permeation Chromatography, HPLC (Prep & Analytical), FPLC, NMR, LCMS-qToF, MALDI-ToF, DSC, TGA, Single-crystal X-ray diffractometer, Electrochemical analyzer, Fluorimeter, TCSPC, Polarimeter, UV-visible, High-resolution FTIR, Raman spectrometers, Microwave reactor, Inverted microscope, Fluorescent microscope, Host-stage polarized microscope, Bio-safety cabinets, CO2 incubators, Shaker incubators, Glove box, Multimode plate reader, Electroporator, Deep freezer, cell counter and Liquid Nitrogn generation plant.

Computational facilities that include a high performance IBM cluster (“Magus”) having 60-node and 992-cores along with two nodes with GPU processors, delivering a theoretical peak performance of ~30TF. Additionally, several Linux workstations are used for teaching as well as research purposes. Software for bioinformatics and cheminformatics, molecular modeling, molecular dynamics, quantum chemistry, data analysis and statistical learning are also available.

Our library, housed in a modern 5-storey building, provides online access, from anywhere in the campus, to a large number of electronic journals and databases including APS, AIP, ACS, RSC, AMS, SIAM, Springer, Elsevier, Wiley and Nature journals, in addition to various books, e-books and other learning resources.

About Shiv Nadar University, Delhi NCR:

Shiv Nadar University (www.snu.edu.in) is a student-centric, multidisciplinary and research-focused University offering a wide range of academic programs at the Undergraduate, Master's and Doctoral levels. The University was set up in 2011 by the Shiv Nadar Foundation, a philanthropic foundation established by Mr. Shiv Nadar, founder of HCL. The University is in the quest to become a globally acclaimed center for learning and innovation in the fields of Engineering, Natural Sciences, Humanities & Social Sciences, and Management. The core of the University consists of a select, world-class faculty with doctoral and postdoctoral experiences from ranked universities all over the world.

Shiv Nadar University has recently been accorded as one of the ten private ‘Institutions of Eminence’ by the Government. In the NIRF (Government’s National Institutional Ranking Framework), the University has been the youngest institution in the 'top 100' Overall list, and its score has been rising steadily. In NIRF-2021, it ranked 56 in the 'University' category. Shiv Nadar University has been accredited with Grade ‘A’ by NAAC (National Assessment and Accreditation Council), valid for a period of five years from 26 November 2019. It is also among a select group of green-field institutions in the country which were awarded the prestigious Atal Incubation Center grant by the NITI Aayog, Government of India, in the very first round in 2017. "