Koyeli Mapa

1. Munan S, Ali M, Yadav R, Mapa K*, Samanta A*. (*co-corresponding authors). PET- and ICT-Based Ratiometric Probe: An Unusual Phenomenon of Morpholine-Conjugated Fluorophore for Mitochondrial pH Mapping during Mitophagy. Anal Chem. 2022 Aug 23;94(33):11633-11642. Impact factor: 6.986 2. Rao KBN, Pandey P#, Sarkar R#, Ghosh A, Mansuri S, Ali M, Majumder P, Kumar KR, Ray A, Raychaudhuri S and Mapa K* (*corresponding author, # equally contributing first authors). Stress responses elicited by misfolded proteins targeted to mitochondria. J Mol Biol. 2022 Jun 30;434(12):167618. Impact factor: 5.469 3. Sadat A, Tiwari S, S Sunidhi, Chaphalkar A, Kocharr M, Ali M, Zaidi Z, Sharma A, Verma K, Rao KBN, Tripathi M, Ghosh A, Gautam D, Atul, Ray A*, Mapa K*, Chakraborty K* (*co-corresponding authors). Conserved and divergent chaperoning effects of Hsp60/10 chaperonins on protein folding landscapes. Proc Natl Acad Sci U S A. 2022 May 3;119(18). Impact factor: 11.2 4. Sarkar R, Rao KBN, Jha MP, Mapa K* (*corresponding author). Endoplasmic reticulum-unfolded protein response pathway modulates the cellular response to mitochondrial proteotoxic stress. Cell Stress Chaperones. 2022 May;27(3):241-256. Impact factor: 3.717 5. Munan S, Kottarathil S, Joseph MM, Jana A, Ali M, Mapa K, Maiti KK, Samanta A. IndiFluors: A New Full-Visible Color-Tunable Donor-Acceptor-Donor (D1-A-D2) Fluorophore Family for Ratiometric pH Imaging during Mitophagy. ACS Sens. 2022 Feb 3. doi: 10.1021/acssensors.1c02381. Impact factor: 7.711 6. Baruah M, Jana A, Ali M, Mapa K, Samanta A. An efficient PeT based fluorescent probe for mapping mitochondrial oxidative stress produced via the Nox2 pathway. J Mater Chem B. 2022 Mar 30;10(13):2230-2237. Impact factor: 6.331 7. Sadat A*, Tiwari S, Mapa K*(*co-corresponding authors). Protocol for Spontaneous and Chaperonin-assisted in vitro Refolding of a Slowfolding Mutant of GFP, sGFP. Bio Protoc. 2021 Jul 20;11(14): e4099. eCollection 2021 Jul 20. Impact factor: 5.78 8. Ali M, Boosi Narayana Rao K, Majumder P, Sarkar R, Mapa K* (*corresponding author). Alterations in inter-organelle crosstalk and Ca2+ signaling through mitochondria during proteotoxic stresses. Mitochondrion. 2021 Mar; 57:37-46. Impact factor: 4.16 (Invited Review Article) 9. Sadat A, Tiwari S, Verma K, Ray A, Ali M, Upadhyay V, Singh A, Chaphalkar A, Ghosh A, Chakraborty R, Chakraborty K, Mapa K (*corresponding author). GROEL/ES Buffers Entropic Traps in Folding Pathway during Evolution of a Model Substrate. J Mol Biol. 2020 Sep 18;432(20):5649-5664. Impact factor: 5.04 10. Kumar V, Peter JJ, Sagar A, Ray A, Jha MJ, Rebeaud ME, Tiwari S, Goloubinoff P, Ashish* and Mapa K* (*corresponding author). Inter-domain communication suppressing high intrinsic ATPase activity of Sse1 is essential for its co-dissaggregase activity with Ssa1. FEBS Journal 2020 Feb;287(4):671-694. Impact factor: 4.75 11. Ghosh A, Gangadharan A, Verma M, Das S, Matai L, Dash DP, Dash D*, Mapa K*, Chakraborty K* (*equally contributing senior authors). Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks. Cell Mol Life Sci. 2019 Apr;76(8):1605-1621. Impact factor: 6.7 12. Banerjee R, Jayaraj GG, Peter J, Kumar V, Mapa K*. (*corresponding author). Monitoring conformational heterogeneity of DnaK lid domain during its functional chaperone cycle. FEBS Journal 2016 Aug;283(15):2853-68. Impact factor: 4.5 13. Banerjee R, Gladkova C, Mapa K, Witte G, Mokranjac D. Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via twodomain coupling protein. Elife. 2015 Dec 29;4. pii: e11897. doi: 10.7554/eLife.11897. Impact factor: 9.32 14. Nagpal S, Tiwari S, Mapa K*, Thukral L* (* co-corresponding authors). Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding. PLoS Comput Biol. 2015Sep 22;11(9):e1004496.. Impact factor: 4.62 15. Kumar S, Mapa K, Maiti S. Understanding the effect of LNA and 2?-O methyl modification on the hybridization thermodynamics of miRNA-mRNA pair in the presence and absence of AfPiwi protein. Biochemistry. 2014 Feb 24. Impact factor: 3.42 16. Sikor M, Mapa K, Voith von Voithenberg L, Mokranjac D, and Lamb DC. Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET. EMBO J. 2013 Apr 26. (2013) 32, 1639 - 1649. Impact factor: 10.0 17. Agarwala P, Pandey S, Mapa K, Maiti S. G-quadruplex augments translation in 5' Untranslated Region of Transforming Growth Factor ?2 (TGF?2). Biochemistry. 2013 Mar 5;52(9):1528-38. Impact factor: 3.42 18. Tiwari S, Kumar V, Jayaraj GG, Maiti S, Mapa K* (*corresponding author). Unique Structural Modulation of a Non-Native Substrate by Cochaperone DnaJ. Biochemistry. 2013 Feb 12;52(6):1011-8. Impact factor: 3.42 (recommended as highly significant paper by F1000) 19. Mapa K*, Tiwari S, Kumar V, Jayaraj GG and Maiti S (*corresponding author). Information encoded in non-native states drives substrate-chaperone pairing. Structure 2012 Sep 5;20(9):1562-73. Impact factor: 6.33 20. Kumar S, Bose D, Suryawanshi H, Sabharwal H, Mapa K, Maiti S. Specificity of RSG1.2 peptide binding to RRE-IIB RNA element of HIV-1 over Rev peptide is mainly enthalpic in origin. PLoS One. 2011;6(8): e23300. Epub 2011 Aug 10. Impact factor: 4.0 21. Popov-Celeketic D, Waegemann K, Mapa K, Neupert W and Mokranjac D. Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex. EMBO Rep. 2011 Jun;12(6):542-8. Impact factor: 7.8 22. Mapa K, Sikor M, Kudryavstev V, Waegemann K, Kalinin S, Seidel CAM, Neupert W, Lamb DC and Mokranjac D. The Conformational dynamics of the mitochondrial Hsp70 chaperone. Mol Cell. 2010 Apr 9;38(1):89-100. Impact factor: 13.5 23. Blamowska M, Sichting M, Mapa K, Mokranjac D, Neupert W and Hell K. ATPase Domain and Interdomain Linker Play a Key Role in Aggregation of Mitochondrial Hsp70 Chaperone Ssc1. J Biol Chem. 2010 Feb 12;285(7):4423-31. Impact factor: 5.5 24. Mokranjac D, Sichting M, Popov-Celeketic D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W. Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria. Mol Biol Cell. 2009 Mar; 20(5):14007. Impact factor: 5.5 25. Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic DA, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D. Interaction of tim23 with tim50 is essential for protein translocation by the mitochondrial tim23 complex. J Biol Chem. 2009 Feb 20;284(8):4865-72. Impact factor: 5.5 26. Popov-Celeketi? D*, Mapa K*, Neupert W, Mokranjac D (*Equally contributing first authors). Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria. EMBO J. 2008 May 21;27(10):1469-80. Impact factor: 8.0 27. Dhar D*, Mapa K.*, Pudi R., Srinivasan P., Bodhinathan K., Das S (*Equally contributing first authors). Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. Arch Virol. 2006 Mar;151(3) :509-24Impact factor: 1.8 28. Bhattacharyya S., Mapa K., Prabhavathi S., Sudhamani SR., Menon PK., John KP, Shivaram C., Amarnath S., Das S. Phylogenetic conservation of the stem-loop III structure of the 5' untranslated region of Hepatitis C virus RNA among natural variants in samples collected from Southern India. Arch Virol. 2004 May; 149(5): 1015-26. Impact factor: 1.8

1. Possible Therapeutic Intervention Strategies for COVID-19 by Manipulating the Cellular Proteostasis Network. Ali M, Rajurkar J, Majumder P, Jha MP, Sarkar R, Mapa K*(*corresponding authors). Adv Exp Med Biol. 2021;1352:125-147. PMID: 35132598 2. Hsp70: a multi-tasking chaperone at the crossroad of cellular proteostasis. Vignesh Kumar and *Koyeli Mapa#. (# Primary and corresponding author). Regulation of Heat Shock Protein Responses, 251-274. Edited by Prof. Alexzander A. A. Asea and Dr. Punit Kaur, Springer, Heat Shock Protein Series (13). 2018. 3. An Overview of Protein Homeostasis Pathways that Safeguard the Cellular Powerhouse from Proteotoxic Stresses. Priyanka Majumder, Mudassar Ali, Rajasri Sarkar, and Koyeli Mapa* (* corresponding author). (accepted for publication in Springer Book Series on Heat Shock Proteins).

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1. Invited lecture titled ?Stress responses elicited by misfolded proteins targeted to mitochondria?, delivered at monthly webinar series organized by Proteomics Society of India (PSI) on 24 June, 2022. 2. Invited lecture in International webinar on Cellular and Protein Homeostasis Webinar Series, titled "Deciphering the sub-mitochondrial compartment specific proteotoxic stress response using S. cerevisiae as a model organism" on February 16, 2021. 3. Invited lecture in a webinar organized by Sharda University, School of Basic Sciences and Research, Department of Chemistry and Biochemistry, titled ?An overview of role of protein quality control machineries in maintaining cellular proteostasis? on May 29th, 2020. 4. Invited lecture at Department of Biology, Ashoka University, Sonepat, in an in-house symposium held on 22nd February 2020. Title of the talk was ?Unravelling subcompartment specific mitochondrial misfolding stress response?. 5. Invited lecture titled ?Mitochondrial protein homeostasis: Why is it important and what are the master regulators of it?? at Biophysica, a symposium on Biophysics held at Jamia Milia Islamia organized by Centre for interdisciplinary research in basic sciences, on 20th November, 2018. 6. Invited lecture at CSIR-IGIB in Protein folding meeting held on 24th March 2018 titled ?Regulation of protein homeostasis?. 7. Invited lecture at RTCMBR at SNU titled ?Deciphering the sub-compartment specific mitochondrial unfolded protein response? on 28th, October 2017. 8. Invited lecture at inStem/NCBS titled ?Deciphering the Protein Quality control pathways and inter-compartment communication during misfolding stress? on 8th November 2016. 9. Invited lecture titled "Study of chaperone-substrate interactions using single molecule FRET" in the International conference on "Recent Advances in Molecular Spectroscopy: Fundamentals and Applications in Materials and Biology (RAMS-2016)" held at School of Chemistry, University of Hyderabad, Hyderabad, India, during March 2?4, 2016

ONGOING RESEARCH PROJECTS 1. SERB Core Research Grant (CRG) as Principal Investigator Project Title: ?Elucidation of role of cytosolic chaperone Sse1, Hsp110 of yeast, during ER stress? PI: Dr. Koyeli Mapa Co-PI: Dr. Ashish Gupta (SNU) Amount Sanctioned: Rs 43,80,663 Duration: 36 months (2020-2023) 2. DBT project under Basic Research in Modern Biology scheme as Principal Investigator, 2nd PI; Dr. Swasti Raychaudhuri (CSIR-CCMB). Project Title: ?A systemic investigation on sub-compartment specific proteotoxicity in mitochondria and the adaptive response mechanisms? PI: Dr. Koyeli Mapa (SNU) and Dr. Swasti Raychaudhuri (CSIR-CCMB) Co-PI: Dr. Richa Priyadarshini (SNU) and R. Sankar Narayanan (CSIR-CCMB) Amount Sanctioned: Rs 80,72,190 (SNU share is Rs 54,75,690) Duration: 36 months (2019-2022) 3. ICMR- Senior Research Fellowship grant as guide Project Title: ?Elucidation of mitochondrial sub-compartment specific proteotoxic stress response in mammalian cells? PI: Mudassar Ali (SRF) and Dr. Koyeli Mapa (guide) Amount Sanctioned (in INR): Rs 13,20,000 Duration: 36 months (2022-2025) 4. ICMR- Senior Research Fellowship grant to Mr. Mainak Pratim Jha Project Title: ?Understanding the non-canonical role of yeast cytosolic Hsp110 molecular chaperone during endoplasmic reticulum stress? PI: Mainak Pratim Jha (SRF) and Dr. Koyeli Mapa (guide) Amount Sanctioned (in INR): Rs 13,20,000 Duration: 36 months (2021-2024) COMPLETED RESEARCH PROJECTS 5. ICMR- Senior Research Fellowship grant as guide Project Title: ?Elucidating the role of TOM complex subunits as potential regulators of Sub-Compartment Specific unfolded protein response in mitochondria? PI: Rajasri Sarkar (SRF) and Dr. Koyeli Mapa (guide) Amount Sanctioned (in INR): Rs 13,20,000 Duration: 36 months (2019-2022) 6. SERB National Post-doctoral grant (NPDF) as Mentor. Project Title: ?To Study Mitochondrial Unfolded Protein Response and Its Crosstalk with Mitophagy in Cell Culture Model Of Huntington's Disease? PI: Dr. Priyanka Majumder (NPDF) CoPI (if any): Dr. Koyeli Mapa (mentor) Amount Sanctioned: Rs 19,20,000, Duration: 24 months (2018-2020) 7. DST-SERB Research Grant under Young Scientist Scheme. Title of the project: "Delineation of conformational allostery of Hsp110 molecular chaperones". PI: Dr. Koyeli Mapa Amount sanctioned Rs 29,36,000. Duration: 36 months (2015-18)

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Member of Board of Reviewing Editors (BRE) of eLife (since 2020 September) Adjunct Professor of Academy of Scientific and Innovative Research (AcSIR) (2018-2021)