Faculty at School of Natural Sciences

Geetanjali Chawla

Geetanjali Chawla

Associate Professor


Contact Information

Age-related Diseases, RNA Biology, model organism genetics, RNA therapeutics development

  • 2002, Ph. D. (Molecular Biology) Indian Institute of Science, Bengaluru, India
  • 1996, M.Sc. (Biotechnology) Maharaja SayajiRao University, Vadodara, India
  • 1994, B.Sc. (Biochemistry) Sri Venkateswara College, Delhi University, India

  • 12/22-Present, Associate Professor, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi-NCR
  • 2022, DBT-Wellcome Intermediate Fellow, Regional Centre for Biotechnology, Faridabad
  • 2017-Present, Adjunct Research Associate Professor, Indiana University, Bloomington, IN, USA
  • 2017, Research Assistant Professor, Indiana University, Bloomington, IN, USA
  • 2012, Postdoctoral Fellow, Indiana University, Bloomington, IN, USA
  • 2008, Postdoctoral Fellow, HHMI, UCLA, CA, USA

  • Manish Pandey, Geetanjali Chawla. Purification of exosome-enriched proteins produced in a Drosophila cell line by size exclusion chromatography. STAR Protocols, Volume 3, Issue 4, 2022, 101834, ISSN 2666-1667, https://doi.org/10.1016/j.xpro.2022.101834
  • Pandey, M., Luhur, A., Sokol, N. S. & Chawla, G. Molecular Dissection of a Conserved Cluster of miRNAs Identifies Critical Structural Determinants That Mediate Differential Processing. Frontiers in Cell and Developmental Biology 10, doi:10.3389/fcell.2022.909212 (2022).
  • Manish Pandey, Sakshi Bansal and Geetanjali Chawla. Evaluation of lifespan promoting effects of biofortified wheat in Drosophila melanogaster, Experimental Gerontology (2022), https://doi.org/10.1016/j.exger.2022.111697.
  • Wilson KA, Chamoli M, Hilsabeck TA, Pandey M, Bansal S, Chawla G**, Kapahi P**. Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience. Cell Metab. 2021 Nov 2;33(11):2142-2173. doi: 10.1016/j.cmet.2021.08.018. Epub 2021 Sep 22. PMID: 34555343. (**Co-corresponding author)
  • Manish Pandey, Divya Ojha, Sakshi Bansal, Ambadas B. Rode**, Geetanjali Chawla**. From bench side to clinic: Potential and challenges of RNA vaccines and therapeutics in infectious diseases. Mol Aspects Med, doi: 10.1016/j.mam.2021.101003. (**Co-corresponding author)
  • Manish Pandey, Sakshi Bansal, Sudipta Bar, Nicholas S. Sokol, Jason M. Tennessen, Pankaj Kapahi** and Geetanjali Chawla**. miR-125-chinmo pathway regulates dietary restriction dependent enhancement of lifespan in Drosophila. eLife 2021;10: e62621 DOI: 10.7554/eLife.62621.  (**Co-corresponding author)
  • Wu YC, Chawla G, Sokol N. let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State. G3 (Bethesda). 2020;10(4):1393-401. Epub 2020/02/20. doi: 10.1534/g3.120.401042. PubMed PMID: 32071070; PMCID: PMC7144073.
  • Bawa S, Brooks DS, Neville KE, Tipping M, Sagar MA, Kollhoff JA, Chawla G, Geisbrecht BV, Tennessen JM, Eliceiri KW, Geisbrecht ER. Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth. Elife. 2020;9. Epub 2020/04/01. doi: 10.7554/eLife.52358. PubMed PMID: 32223900; PMCID: PMC7105379.
  • Krejčová G, Danielová A, Nedbalová P, Kazek M, Strych L, Chawla G, Tennessen JM, Lieskovská J, Jindra M, Doležal T, Bajgar A. Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense. Elife. 2019 Oct 14;8. pii: e50414. doi: 10.7554/eLife.50414.
  • Hongde Li, Madhulika Rai, Kasun Buddika, Maria C. Sterrett, Arthur Luhur, Nader H. Mahmoudzadeh, Cole R. Julick, Rose C. Pletcher, Geetanjali Chawla, Chelsea J. Gosney, Anna K. Burton, Jonathan A. Karty, Kristi L. Montooth, Nicholas S. Sokol and Jason M. Tennessen. (2019) Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development.  Development Posted Online August 9, 2019, doi:10.1242/dev.175315.
  • Geetanjali Chawla (2019). Healthy Aging research in India.  Journal of Experimental research on human growth and Aging. Vol. 2, Issue 1, Aug. 28, 2019.
  • Li H, Chawla G, Hurlburt AJ, Sterrett MC, Zaslaver O, Cox J, Karty JA, Rosebrock AP, Caudy AA, Tennessen JM. (2017) Drosophila larvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth.  Proc Natl Acad Sci U S A. 114:1358.
  • Chawla G#, Luhur A#, Sokol NS. (2017) Analysis of MicroRNA Function in Drosophila.  Methods Mol. Bio. 1478:94. (# Co-authors)
  • Chawla G**, Deosthale P, Childress S, Wu YC, Sokol NS**. (2016) A let-7-to-miR-125 MicroRNA Switch Regulates Neuronal Integrity and Lifespan in Drosophila. PLoS Genet. 12: e1006247. (**Co-corresponding author)
  • Chawla G**, Sokol NS**. (2014) ADAR mediates differential expression of polycistronic microRNAs.  Nucleic Acids Res. 42:5255. (**Co-corresponding author)
  • A Luhur, G Chawla#, YC Wu#,1 J Li, NS Sokol. (2014) Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis. Proc Natl Acad Sci U S A. 111:1426. # Co-authors
  • Luhur A#, Chawla G#, Sokol NS. (2013) MicroRNAs as components of systemic signaling pathways in Drosophila melanogaster. Curr Top Dev Biol. 105:123. (# Co-authors)
  • Chawla G**, Sokol NS**. (2012) Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function. Development. 139:1797. (**Co-corresponding author)
  • Chawla G**, Sokol NS**. (2011) MicroRNAs in Drosophila development. Int Rev Cell Mol Biol. 286:65. (**Co-corresponding author)
  • Zheng S, Gray EE, Chawla G, Porse BT, O'Dell TJ, Black DL. (2012) PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2. Nat Neurosci. 15:381-8.
  • Tang ZZ, Sharma S, Zheng S, Chawla G, Nikolic J, Black DL. (2011) Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein. J Biol Chem. 286:10007-16.
  • Chawla G, Lin CH, Han A, Shiue L, Ares M Jr, Black DL. (2009) Sam68 regulates a set of alternatively spliced exons during neurogenesis. Mol Cell Biol. 29:201-13.
  • Boutz PL, Stoilov P, Li Q, Lin CH, Chawla G, Ostrow K, Shiue L, Ares M Jr, Black DL. (2007) A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev. 21:1636-52.
  • Boutz PL, Chawla G, Stoilov P, Black DL. (2007) MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Genes Dev. 21:84.
  • Chawla G, Sapra AK, Surana U, Vijayraghavan U. (2003) Dependence of pre-mRNA introns on PRP17 a non-essential splicing factor: implications for efficient progression through cell cycle transitions.  Nucleic Acid Research. 31:2343.
  • Lindsey-Boltz LA#, Chawla G#, Srinivasan N, Vijayraghavan U, Garcia-Blanco MA. (2000) The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function.  RNA. 6:1289-305. (# Co-authors)

 

  • Manish Pandey and Geetanjali Chawla. Total RNA isolation from Drosophila using TRIzol based reagent. In: H. A. Ranganath and S.C. Lakhotia (eds) Experiments with Drosophila for Biology Courses. (2021) pp 341-350 Indian Academy of Science, Bengaluru, India.
  • Manish Pandey, Sakshi Bansal and Geetanjali Chawla. Genomic DNA isolation from Drosophila. In: H. A. Ranganath and S.C. Lakhotia, (eds) Experiments with Drosophila for Biology Courses. (2021) pp 329-335. Indian Academy of Science, Bengaluru, India.
  • Pandey M., Bansal S., Chawla G (2020). Molecular Approaches for Analysis of Drosophila MicroRNAs. In: Mishra M. (eds) Fundamental Approaches to Screen Abnormalities in Drosophila. Springer Protocols Handbooks. pp 169-188. Springer, New York, NY.
  • **Geetanjali Chawla and **Sokol NS. MicroRNA pathways in Drosophila. From Nucleic Acids Sequences to Molecular Medicine 2012[Springer book]. (**Co-corresponding author)

  • Presented talk titled “Molecular dissection of a conserved cluster of microRNAs”, at the 11th RNA Group meeting, organized by NCCS, Pune, December 1, 2022.

  • Post-transcriptional regulators of aging and dietary restriction, Geetanjali Chawla (PI), DBT-Wellcome Trust, India Alliance Intermediate Fellowship (INR 359 Lakhs) (6 years).