Faculty at School of Natural Sciences

Tatini Rakshit

Tatini Rakshit

Assistant Professor

School of Natural Sciences


Contact Information

Chemical Biology, Force-Based Microscopy and Spectroscopy.

Webpage: Click Here

2014

Ph.D. Indian Association for the Cultivation of Science, Kolkata

2008

M.Sc. Jadavpur University, Kolkata

2006

B.Sc. Jadavpur University, Kolkata

12/21 - Present

Assistant Professor, Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Delhi-NCR

11/18-11/21

DST Inspire Faculty Fellow, S. N. Bose National Centre for Basic Sciences, Kolkata

10/16-08/18

Postdoctoral Fellow, National Cancer Institute (NCI), National Institute of Health (NIH), Bethesda, MD

03/14-09/16

Postdoctoral Fellow, Case Western Reserve University, School of Medicine, Cleveland, Ohio

  1. DST-Inspire faculty fellowship and grant (2017-Session II) in Chemical sciences. Received “Excellent” grade in the final evaluation by the DST expert committee, July 2023.
  2. NIH Postdoctoral Fellowship (2016-2018).
  3. Qualified in National Eligibility Test (UGC/CSIR NET) Examination (December 2007), Junior and Senior Research Fellowship (2008-2013).
  4. Indira Gandhi Post Graduate Scholarship by University Grants Commission (2006-2008).
  5. National Merit Certificates from the Education Department, Government of West Bengal, for Madhyamik (ranked 56) and Higher Secondary (ranked 65) Examinations in 2001 and 2003.

  1. Received a complimentary, year-long membership of the American Chemical Society at the premium package level in recognition of her recent efforts as an ACS Peer reviewer, 2023 and 2024
  2. Life member of the Indian Society of Extracellular Vesicles, the Indian Biophysical Society, and CRSI.
  3. Received an appointment as Early Career Editorial Board Member of Extracellular Vesicles and Circulating Nucleic Acids https://www.oaepublish.com/evcna (IF 4.0).
  4. Her interview on how open access is transforming the academic landscape for researchers and authors in India, ACS axial post https://go.acs.org/blc

  1. Amino acid-modified G-quartet hydrogel for glucose-responsive insulin release in vivo, D. Jinagal, Natasha, D. Paul, R. Prajapati,   T. Rakshit*,     S. Pal*, Chemical Communications. 2025. DOI:  10.1039/D5CC05351J.
  1. Improved Diabetic Wound Healing via Flower Extracellular Vesicles and Carbon-Dot-Infused Alginate-Polyethylenimine Antibacterial Hydrogel, S. Zaffar, S. Saha, T. Agrawal, S. Gupta, P. Gulati, D. Paul, A. Verma, S. Pal*, T.Rakshit*, ACS Biomaterials Science and Engineering. 2025. DOI:  10.1021/acsbiomaterials . 5c00443. (invited article)
  1. High-Resolution Analysis of Human Centromeric Chromatin. D. Melters, M. Bui, T. Rakshit, S. Grigoryev, D. Sturgill, Y Dalal*, Life Science Alliance. 2025. DOI: 10.26508/lsa.202402819.
  1. Glucose-responsive Materials for Smart Insulin Delivery: from Protein-based to Protein-free Design. S. Pal*, T. Rakshit, S. Saha, D. Jinagal, ACS Materails Au. 2025. DOI:10.1021/acsmaterialsau.4c00138 (invited article)
  1. Epigenetic Modifier Drug Valproic Acid Enhances Cancer Metaphase Chromosome Elasticity and Electron Transport: An Atomic Force Microscopy Approach. T. Agrawal, D. Paul, S. Bera, A. Mishra, A. Ganesan, T. Rakshit*, JACS Au. 2025. DOI: 10.1021/jacsau.4c00991 (highlighted by Hindu, Times of India and many other leading newspapers)
  1. Unveiling the Electrical Properties of Hyaluronan-Coated Cancer Extracellular Vesicles Using Correlative Scanning Probe Microscopy-Based Nano-Electrical Modes. D. Paul, S. Bera, T. Agrawal, N. Karmodak, T. Rakshit*, ACS Applied Materials and Interface. 2025. DOI: 10.1021/acsami.4c17247.
  1. Plant Extracellular Nanovesicle-Loaded Hydrogel for Topical Antibacterial Wound Healing In Vivo. S. Saroj, S. Saha, A. Ali, S. Gupta, A. Bharadwaj, T. Agrawal, S. Pal*, T. Rakshit*, ACS Applied Biomaterials. 2024. DOI: 10.1021/acsabm.4c00992. (Artwork selected as Front Cover)
  1. In-situ Forming Multipolymeric Glucose-responsive Hydrogels. S. Saha, A. Ali, S. Saroj, D. Jinagal, T. Rakshit, S. Pal* Chemistry, an Asian Journal. 2024. DOI: 10.1002/asia.202400873.
  1. Catalyst Free Synthesis of 4-Aryl/Alkylamino-1,2- Naphthoquinones: Applications in Fluorescence Microscopy. B. Nagar, T. Agrawal, T. Rakshit, B. . Dhar* Chemistry Select.  2024. DOI: 10.1002/slct.202402531.
  1. DNA-Assembled SERS-active Multimeric Nanoparticle Structures. T. Rakshit*, P. Gulati, S. Khaitan, S. Pal* ACS Applied Optical Materials.  2024. DOI: 10.1021/acsaom.4c00072. (invited review)
  1. E-Protein Protonation Titration-Induced Single Particle Chemical Force Spectroscopy for Microscopic Understanding and pI Estimation of Infectious DENV, M. Ghosal, T. Rakshit*, S. Bhattacharya, S. Bhattacharyya, P. Satpati*, Dulal Senapati*, Journal of Physical Chemistry B, 2024, DOI: 10.1021/acs.jpcb.4c00057
  1. Extracellular Vesicles in Dug Delivery and Theranostics in vivo, T. Rakshit*, S. Pal*, JACS Au (Invited perspective article), 2023, DOI : 10.1021/jacsau.3c00611.
  1. Herb Extracellular Vesicle-Chitosan-PEGylated Graphene Oxide Conjugate Delivers Estrogen Receptor Alpha Targeting siRNA to Breast Cancer Cells, S. Saroj, U. S. Poornima, S. Patil, D. Paul, A. Ali, S. Saha, S. Pal*, B. Lochab*, T. Rakshit*, ACS Applied Biomaterials, 2024 , DOI: 10.1021/acsabm.3c01108
  1. Probing Aberrantly Glycosylated Mucin 1 in Breast Cancer Extracellular Vesicles. S. Saroj#, D. Paul#,Ali, C. Andreou, S. Pal*, T. Rakshit*, ACS Applied Biomaterials, 2023,    DOI: 10.1021/acsabm.3c00651
  1. Single-Molecule Analysis of CENP-A Chromatin by High-Speed Atomic Force Microscopy. D. P. Melters , K. C. Neuman, R. S Bentahar, T. Rakshit, Y. Dalal*, eLife, 2023, DOI: 10.7554/eLife.86709.
  1. Glucose-Responsive Chitosan Nanoparticle / Poly (vinyl alcohol) Hydrogels for Sustained Insulin Release In Vivo. A. Ali, S. Saroj#, S. Saha#, S. K. Gupta, T. Rakshit*, S. Pal*, ACS Applied Materials and Interfaces, 2023, DOI: 10.1021/acsami.3c05031 (highlighted by Times of India and many other leading newspapers).
  1. T. Agrawal, D. Paul, S. Saroj, S. Pal*, T. Rakshit*, Label-free Physical-Analytical Techniques Reveal Epigenetic Modifications of Breast Cancer Chromosomes, Journal of Physical Chemistry B, 2023, DOI: 10.1021/acs.jpcb.3c00147. Published as part of The Journal of Physical Chemistry virtual special issue “Early-Career and Emerging Researchers in Physical Chemistry Volume 2"
  1. A. Ali, S. Saroj, T. Rakshit*, S. Pal*, Glucose-responsive Protein Polymer Hydrogels: Effects on Insulin Release Kinetics, ACS Applied Biomaterials, 2023, DOI: 10.1021/acsabm.2c00951.
  1. D. Paul#, D. Mukherjee#, A. Paul#, Saroj S., M. Ghoshal, S. Pal*, D. Senapati*, J. Chakrabarti*, S.K. Pal*, T. Rakshit*, A Mechanoelastic Glimpse on Hyaluronan-Coated Extracellular Vesicles, The Journal of Physical Chemistry Letters, 2022, DOI: 10.1021/acs.jpclett.2c01629, This work has been highlighted by DST media cell (https://dst.gov.in/sugar-coated-pouches-body-fluids-can-help-detect-cancer)
  1. A. Pramanik*, A. Ghatak, S. Khanra, D. Das, T. Rakshit, S. Bhar*, Metal Free Approach towards the Synthesis of Structurally Diverse 1, 2-Dihydronaphthalene Scaffolds and Theoretical Investigation, ChemistrySelect, 2022, DOI: 10.1002/slct.202201159
  1. S. Pal*, J. Koneru, C. Andreou, T. Rakshit, V. Rajasekhar, M. Wlodarczyk, J. Healey, M. Kircher, J. Mondal, DNA-functionalized Gold Nanorods for Perioperative Optical Imaging and Photothermal

Therapy of Triple-negative Breast Cancer, ACS Applied Nanomaterials, 2022, DOI:10.1021/acsanm.2c01502

  1. A. Ali, N. Shaista, S. Saroj, M. Shegane, P. Majumder, A. Puri, T. Rakshit, D. Manna, S. Pal*, Repurposing Pinacol Esters of Boronic Acids for Tuning Viscoelastic Properties of Glucose-responsive Polymer Hydrogels: Effects on Insulin Release Kinetics, Journal of Materials Chemistry B, 2022 , DOI: 10.1039/D2TB00603K
  1. D. Mukherjee, G. Chakraborty, Md. N. Hasan, U. Pal, T. Rakshit, R. I. Alsantali Dis, T. Saha Dasgupta, Ranjan Das, S. K. Pal*, Reversible photoswitching of spiropyran in biomolecular interfaces: A combined spectroscopy and computational study, Journal of Photochemistry and Photobiology, A: Chemistry, 2022, DOI: /10.1016/j.jphotochem.2022.113958
  1. B. Datta, D. Paul, T.Dey, S. Pal*, T. Rakshit*, Importance of Extracellular Vesicle Derived RNAs as Critical Colorectal Cancer Biomarkers, ACS Bio & Med Chem Au (Invited review article), 2022, DOI: 10.1021/acsbiomedchemau.1c00043
  1. D. Mukherjee#, D. Paul#, S. Sarker#, Sushmita; Md. N. Hasan, R. Ghosh, S. Prasad, P. Vemula, R. Das, A. Adhikary, Arghya, S. K. Pal*, T. Rakshit*, PEG Mediated Fusion of Extracellular Vesicles with Cationic Liposomes for the Design of Hybrid Delivery Systems, ACS Applied Biomaterials, 2021 DOI: 10.1021/acsabm.1c00804
  1. S.Pal*, T. Rakshit, Folate-functionalized DNA Origami for Targeted Delivery of Doxorubicin to Triple-negative Breast Cancer, Front. Chem., 2021, DOI: 10.3389/fchem.2021.721105
  1. A. Ali, S. P. Nagumantri, T. Rakshit, S. Pal*, Control of Glucose-induced Degradation and Cargo Release in Multi-responsive Polymer Hydrogels, Macromolecular Chemistry and Physics, 2021 (selected as back cover article), DOI:10.1002/macp.202100121. .
  1. B. Dutta#, D. Paul#, U. Pal*, T. Rakshit*, Intriguing Biomedical Applications of Synthetic and Natural Cell-Derived Vesicles: A Comparative Overview (Review article), ACS Applied Biomaterials, 2021, DOI: 10.1021/acsabm.0c01480
  1. D. Paul, A. Roy, A. Nandi, B. Dutta, P. Borar, S. K. Pal, D. Senapati, T. Rakshit*, Identification of Biomarker Hyaluronan on Colon Cancer Extracellular Vesicles Using Correlative AFM and Spectroscopy, The Journal of Physical Chemistry Letters, 2020, DOI: 10.1021/acs.jpclett.0c01018 , This work has been              highlighted        by          DST       media cell https://pib.gov.in/PressReleseDetailm.aspx?PRID=1639974 and featured in IndiaBioscience (TIFR publication) https://indiabioscience.org/news/2020/a-nanosized-tool-to-non-invasively-detect-cancer- cells
  1. T Rakshit*, D. Melters, E. Dimitriadis M. Bui, Y. Dalal*, Mechanical properties of nucleoprotein complexes determined by nanoindentation spectroscopy, Nucleus (methods), 2020, DOI: 10.1080/19491034.2020.1816053
  1. D. Mukherjee, T. Rakshit*, P. Singh, S. Mondal, D.Paul, M. Ahir, A. Adhikary, P. K. Vemula, D. Senapati, R. Das*, S. K. Pal*, Differential Flexibility Leading to Crucial Microelastic Properties of Asymmetric Lipid Vesicles for Cellular Transfection: A Combined Spectroscopic and Atomic Force Microscopy Studies, Colloids and Surfaces B: Biointerfaces, 2020, DOI: 10.1016/j.colsurfb.2020.111363
  1. T Rakshit*, S. Bera, J. Kolay, R. Mukhopadhyay*, Nanoscale Solid-state Electron Transport via Ferritin: It’s Implication in Molecular Bioelectronics, Nanostructures and Nano-objects (Invited perspective article), 2020, DOI: 10.1016/j.nanoso.2020.100582
  1. D. Mukherjee, P. Singh, T. Rakshit, P. Vemula, J. Sengupta, R. Das, S. K. Pal*, Deciphering the Response of Asymmetry in Hydrophobic Chains of Novel Cationic Lipids towards Biological Function, Phys. Chem. Chem. Phys., 2019, DOI: 10.1039/C9CP05405G

  • Keynote Lecture @AIIMS Exosome Workshop, Sept 1-10th, 2025.
  • Invited Speaker at Deshbandhu College, Biospark conference, Nov, 4, 2025
  • Invited Speaker at ACS Global Scientific Conference, IIT Bombay, Oct 8-11, 2025
  • Invited Speaker at CACS-2025 conference @Ashoka University, 8-9 March 2025
  • Invited Speaker at the Dr. Aditi Simha Memorial Symposium, IIT Madras, on 7th January 2025.
  • Invited Speaker at Departmental Colloquium, Bose Institute, Kolkata, on 19th December 2024
  • Invited Speaker at the OWLS-17, IIT Bombay, from 19-21 November 2024.
  • Received invitation to attend the INSA-ACS Faculty Leadership Summit during Nov 3-5, 2023, and delivered a ‘Lightning Talk’ at the in-person ACS Editor Interaction with Prof. Erick M. Carreira scheduled on Nov 6, 2023, INSA, New Delhi
  • Invited Speaker at the workshop on "Inspiring women in science and technology", NIT Patna (18th- 22nd Sept 2023)
  • Invited Speaker at the national conference on "Force Spectroscopy and Microscopy", @GarudMaachi, Pune (24th-26nd June 2023) organised by IISER Pune
  • Invited speaker at Young Scientist Conclave, Indian Chemical Society, July 31, 2022.
  • Invited speaker at Gangeya Student Chapter, "Biophysics Week Celebration", organized by IISER Kolkata, March 27, 2021.
  • Invited speaker at Soft Matter Young Investigators’ Meet (SMYIM), May 12-14, 2019, Shillong, India

  • Shiv Nadar Foundation Collaboration Grant (2025-2028), 40 lakhs as co-PI

Title of the project: Nanomedicine for Breast Cancer: Exosome Carriers with Thermal Agents and Nanothermometer for Effective Therapy and Monitoring

  • Core Research Grant, (2023-2026), 58 lakhs (Interdisciplinary Life Sciences) as co-PI

Title of the project: Deciphering mechano-chemical cues of epithelial-mesenchymal transition in cancer by developing DNA origami-based artificial extracellular matrix

  • Core Research Grant, (2020-2023), 47 lakhs (Interdisciplinary Life Sciences) as PI

Title of the project: Quantitative study on single-chromosome elasticity and its relevance to chromosome fragility in cancer.

  • DST-Inspire faculty grant (2018-2023), 35 lakhs (Chemical Science) as PI

Title of the project: Biophysical characterization of extracellular vesicles (EVs) using single molecule detection (SMD) methods: a potential non-invasive diagnostic tool.

  1. Recent Advances in Multifunctional Biomacromolecules for Cancer Theranostics, Editor: T. Bhowmik (Invited Book Chapter), S. Saroj, T. Rakshit*, S. Paul*, Taylor & Francis publications, 2024
  1. AFM-based Mechanobiology of Extracellular vesicles “Extracellular vesicles as matrix messengers” for the Book Series "Biology of Extracellular Matrix“. Editor: Prof. Kirsi Rilla (Invited Book Chapter), D. Paul, S. Saroj, T. Agrawal, Suchetan Pal*, T. Rakshit*, published by Springer, 2023.
  1. AFM-based Mechanobiology of Extracellular vesicles, Extracellular vesicles as matrix messengers, for the Book Series "Biology of Extracellular Matrix“. Editor: K. Rilla (Invited Book Chapter), D. Paul, S. Saroj, T. Agrawal, T. Rakshit*, published by Springer, 2023.
  1. Physical and Analytical tools to identify Cancer Biomarkers from Extracellular Vesicles, Emerging trends in Medical biotechnology: in vivo, in vitro, in silico. Editor: P. Talukder (Invited Book Chapter), S. Saroj#, D. Paul#, U. S. Poornima#, T. Rakshit*, Taylor & Francis publications, 2022.

  • The Journal of Physical Chemistry Letters, 2022, DOI: 10.1021/acs.jpclett.2c01629, This work has been highlighted by DST media cell (https://dst.gov.in/sugar-coated-pouches-body-fluids-can-help-detect-cancer)
  • The Journal of Physical Chemistry Letters, 2020, DOI: 10.1021/acs.jpclett.0c01018 , This work has been highlighted by DST media cell ( (https://pib.gov.in/PressReleseDetailm.aspx?PRID=1639974 ) and featured in IndiaBioscience (TIFR publication) https://indiabioscience.org/news/2020/a-nanosized-tool-to-non-invasively-detect-cancer- cells

Patents:

Tatini Rakshit, Saroj, Aditi Bharadwaj, Sprayable formulation for button mushroom preservation, Indian Patent Application No.: No.202511074031 , Aug 29, 2025.

Peer Review Service:

ACS Applied Biomaterials, ACS Applied Materials & Interfaces, ACS Applied Nanomaterials, ACS Applied Polymeric Materials, ACS Omega, Advanced Materials, Advanced Science, Analytical Biochemistry, Biophysical Chemistry, Biosensors and Bioelectronics, BMC Cancer, Journal of Surface Science and Technology, Langmuir, Nucleic Acids Research, Physical Chemistry Chemical Physics, Ultramicroscopy.

  • Secretary, International Chemical Biology & Molecular Imaging Conference (iCBMIc-2025), 7-9 November, 2025
  • Organizing team member , Workshop and International Conference Modern Aspects of Green & Sustainable Organic Synthesis (MAGSOS-2024), 26-29 Nov 2024, SNU and HEIA-FR Switzerland.
  • Organizing team member , AFMSA-2024 Conference (Advanced Functional Materials for Sustainable Applications), Feb 9-10, 2024, RSC, and DST sponsored.
  • Organizing team member, Yusuf Hamied Chemistry Camp & Chemistry Fair 2023 on 9th - 11th February 2023.
  • Organizing team member, Chemistry Fair 2022 (Moto: Learning by doing) by the Chemistry Department. 25-26TH March 2022.