Seminar by Dr. Upendra K. Sharma on Scaling Visible Light Photoredox Catalysis in Flow: Turning Photons into Chemical Bonds

The development of new and benign strategies facilitating the atom-economical construction of biologically and industrially important molecules is a key pursuit from the viewpoint of Sustainable Chemistry. Construction of carbon-carbon and carbon-nitrogen bonds via the generation of carbon or nitrogen centered radicals is a rapidly growing field in the realms of synthetic organic chemistry.[1] In this direction, visible light photocatalysis has been playing a tremendous role for the translation of odd-electron transfer processes into mild catalytic cycles that have previously been elusive in comparison to their two-electron analogues.[2] However, to make a long standing impact and wide applicability in pharmaceutical industry, medicinal chemistry as well as material sciences, visible-light photocatalysis has to deal with scale-up as well as severe solubility issues associated with the stoichiometric use of inorganics or the use of charged substrates. This presentation will highlight and discuss our efforts in this direction,[3] how photo(flow)chemistry[4] can solve these issues when combined with right substrates and catalyst under mild reaction conditions, besides its application in pharmaceutical synthesis (Scheme 1).

Scheme 1: Photocatalytic C-C bond formations in batch and continuous flow.

References

[1] a) D. Ravelli, S. Protti, M. Fagnoni, Chem. Rev2016116, 9850; b) M. D. Levin, S. Kim, F. D. Toste, ACS Cent. Sci20162, 293.

[2] a) M. H. Shaw, J. Twilton, D. W. C.  MacMillan, J. Org. Chem2016, 81, 6898; b) D. M. Schultz, T. P. Yoon, Science 2014, 343, 1239176.

[3]  a) U. K. Sharma, H. P. L. Gemoets, F. Schrӧder, T. Noël, E. V. Van der Eycken, ACS Catal. 2017, 7, 3818; b) F. Lima, U. K. Sharma, L. Grunenberg, D. Saha, S. Johannsen, J. Sedelmeier, E. V. Van der Eycken, S. V. Ley, Angew. Chem. Int. Ed., 2017, 56, 15136.

[4]  U. K. Sharma, E. V. Van der Eycken (Vol. Ed.) Flow chemistry for the synthesis of Heterocycles, in: topics in heterocyclic chemistry B. Maes, J. Cossy, S. Polanc, (Series Ed.), 2018, Springer.                      

Event Date: 
Tuesday, September 18, 2018 -
12:0013:00

The Department of Chemistry, School of Natural Sciences had invited Dr. Upendra K. Sharma from Laboratory for Organic & Microwave Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Belgium for a Seminar as per the below details:

Date: Tuesday, 18th September 2018

Time: 12.00 – 1.00 PM

Seminar Title: “Scaling Visible Light Photoredox Catalysis in Flow: Turning Photons into Chemical Bonds

Venue: D330

Tuesday 18, Sep 2018
12:00 PM - 01:00 PM
D330

Directions