Chemistry Ph.D. Viva-Voce of Ms. Tania Luthra on 15th July 2019 | Shiv Nadar University
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Chemistry Ph.D. Viva-Voce of Ms. Tania Luthra on 15th July 2019

Event Date: 
Monday, July 15, 2019 -
09:3010:30

Ph.D. viva-voce of Ms. Tania Luthra, Department of Chemistry, School of Natural Sciences is scheduled as below:

Date: 15th July 2019    

Time: 9.30 – 10.30 AM   

Venue: D330   

 

Thesis Title: Design of Novel Molecular Libraries as Inhibitors of alpha-glucosidase- Potent Hybrid Compounds Against Type II Diabetes

 

Advisor: Dr. Subhabrata Sen (Dept. of Chemistry)

External Examiner: Professor Parthasarathi Das, Associate Professor,  Department of Applied Chemistry, Indian Institute of Technology (Indian School of Mines), Dhanbad

Internal Examiner: Dr. Bimlesh Lochab (Dept. of Chemistry)

Chair: Dr. Parthapratim Munshi (Dept. of Chemistry)

 

All are cordially invited.

 

Abstract: Diabetes Mellitus is one of the most widespread metabolic disorders in the world and nearly 200 million global population is affected from diabetes. Type I diabetes is caused because of insulin deficiency and it has affected nearly 5-10% of the diabetic population.  However, type II diabetes which is most common is mainly due to insulin resistance. Diabetes is characterized by hyperglycemia that is associated with various complications such as cardiac and vascular diseases, thrombosis, cerebral and renal disorders. The worldwide prevalence of diabetes in all age groups has been rising and it is estimated that it might increase from 2.8% (171 million) in the year 2000 to 4.4% (~ 400 million) in 2030. In case of Type II diabetes inhibition of  alpha-glucosidase enzyme is an effective therapeutic approach which involves controlling postprandial hyperglycemia by delaying the digestion of carbohydrates. Therefore, inhibition of  alpha-glucosidase enzyme slows down the carbohydrate absorption. This stabilizes the blood glucose level among diabetic patients, thereby preventing hyperglycemia. Effective treatment of diabetes mellitus is currently limited to oral  alpha-glucosidase inhibitors viz. acarbose, miglitol and voglibose, However they are impaired by efficacy problems and unwanted side effects. These drugs were discovered more than three decades ago with no further significant progress in the drug development area of anti-diabetic alpha-glucosidase inhibitors.Hence, it is the need of the hour to identify a novel alpha-glucosidase inhibitor. This thesis mainly consist of five chapters describing the evaluation of potent  alpha-glucosidase inhibitor for treatment of diabetes. First chapter introduces diabetes and it’s therapeutic approaches and also it describes various existing potent inhibitors. Second chapter involves design, synthesis, in vitro and in vivo studies of a novel library of a-arylketones as potential inhibitors of a-glucosidase. Chapter three includes detailed study of design, synthesis and in vitro study of densely functionalized oxindoles as potent alpha-glucosidase inhibitors. Fourth and fifth chapter describes the design and synthesis of novel pyridone based alpha-glucosidase inhibitors along with their biological evaluation, in vitro ADME-Tox, in vivo pharmacokinetics and efficacy studies.    

List of Publications (to be included in the thesis):

Tania Luthra, Rahul Agarwal, Uma Adepally,* Mamidala, Estari, Subhabrata Sen*, A novel library of alpha-arylketones as potential inhibitors of alpha-glucosidase: Their design, synthesis, in vitro and in vivo studies, Scientific Reports20177, 13246.

Tania Luthra, K. Naga Lalitha, Rahul Agarwal, Uma Adepally and Subhabrata Sen*, Synthesis, design and in vitro study of densely functionalized oxindoles as potent alpha-glucosidase inhibitors. Bioorganic Med. Chem., 2018, 26, 4996-5005.

Tania Luthra, Venkana Bonuthu, Uma Adepally, Krishna Kumar, Swathi M, Saikat Chakrabarti, Srinivas R. Maddi and Subhabrata Sen*, Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of Type 1 diabetes. (Manuscript in Submission)  

List of Publications (not to be included in the thesis):  

Tania Luthra§, Akshay Kumar Nayak§, Sarpita Bose, Saikat Chakrabarti, Ashish Gupta* and Subhabrata Sen*, Indole based antimalarial compounds targeting the melatonin pathway: Their design, synthesis and biological evaluation. European Journal of Medicinal Chemistry2019, 168, 11-27 (§ Equal contributor).

Jyoti Chauhan,§ Tania Luthra§ and Subhabrata Sen*, An iodine catalyzed metal free oxidative ring opening of 1-aryltetrahydro-b-carbolines: Facile synthesis of C2 aroyl and aryl methanimino indole derivatives. European Journal of Organic Chemistry, 2018, 4776-4786. (§ Equal contributor).

Jyoti Chauhan, Tania Luthra, Rambabu Gundla, Antonio Ferraro, Ulrike Holzgrabe, Subhabrata Sen*, A diversity oriented synthesis of natural product inspired molecular libraries. Organic and Biomolecular Chemistry201715, 9108-9120.

Ganesh Lenin Kandasamy, Atul Sudame, Tania Luthra, Kalawati Saini, Dipak Maity*, Functionalized hydrophilic superparamagnetic iron oxide nanoparticles for magnetic fluid hyperthermia application in liver cancer treatment. ACS Omega20183, 3991-4005. 

Jyoti Chauhan, Moumita Dasgupta, Tania Luthra, Akanksha Awasthi, Sayantan Tripathy, Anindyajit Banerjee, Santunu Paul, Debashish Nag, Saikat Chakrabarti, Gopal Chakrabarti and Subhabrata Sen*, Design, synthesis and biological evaluation of a novel library of antimitotic C2 – aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO). European Journal of Pharmaceutical Chemistry2018, 124, 249-265. 

Dandugudumula Ramu, Ravi Jain, Ravi Ranjan Kumar, Veena Sharma, Swati Garg, Ayana Rajgopal, Tania Luthra, Preeti Yadav, Subhabrata Sen, Shailja Singh*, Design and synthesis of imidazolidinone derivatives as potent anti-leishmanial agents by bioisosterism. Archiv der Pharmazie, 2019, e1800290 (DOI: 10.1002/ardp.201800290).

Monday 15, Jul 2019
09:30 AM - 10:30 AM
D330

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