Department of Life Sciences,
School of Natural Sciences
Ph.D in Biomedical sciences, Faculty of Medical Sciences, Univesity of Delhi, Delhi.
Masters in Biotechnology, GGD Central University, Bilaspur.
Bachelors in Biology, Utkal University, Orissa.
2011-2014: Postdoctoral Fellow, Baylor College of Medicine, Texas, USA. Principal Investigator, Autism Speaks Translational Postdoctoral grant Award.
2009-2011: USM Postdoctoral Fellow, Department of Neuroscience, School of Medical Sciences, University Science Malaysia, Malaysia
2008-2009: Senior Research Fellowship/Research Associate, Gene Regulation Laboratory National Institute of Immunology New Delhi-67, India
The research goal of my laboratory is to understand the tightly regulated cellular and molecular paradigm underlying neurodevelopmental process. We are deeply interested to unravel the factors which strongly influences altered neuronal development and brain connectivity patterns in neurodevelopmental disorders linked to severe cognitive impairments, especially in autism spectrum disorder (ASD). ASD affects every 1 out of 250 in India and 1 out of 68 in USA. Most of the autistic patients are idiopathic (75%) and represents complex heterogeneity in terms of brain connectivity and attenuated neural networks, related to altered cognition and perception. To understand the brain connectivity maps and metabolic circuits in autism, we are focussed on three research areas involving;
cellular neurobiology, neuroimaging and integrated system biology based applications
Cellular Neurobiology- to decode altered metabolic imprints in autistic patient-derived neural progenitor cells and microglia
. Recent clinical findings involving post-mortem autistic brains have shown distorted and activated morphology of microglia. Besides playing the role as brain scavengers, these microglia are found to under prune or over trim neurons leading to damaged functional synapses, under neuropathogenic stimulations. During normal neuronal development, these microglia control the neural progenitor cell (NPC) pool in brain by phagocytosis, as shown by recent murine model based studies. To understand the metabolic changes pertinent to activity of microglia and NPCs in autism, we will generate patient-specific induced Pluripotent stem cell (iPSC) lines using blood mononuclear cells. These iPSC line will be induced to make generate induced neural progenitor cells (iNPCs) and induced microglia (iMG). Further, altered metabolic imprints from these cells using MS-Spec based metabolomics and RNA-sequencing based transcriptomics will provide guidance cues to onset of metabolic alterations.
Integrated system biology- to generate neural metabolic-to-transcriptomic map by in silico mapping to SFARI and Allen Brain Institute data bases
. To ascertain altered metabolic genes, in iNPCs & iMGS, Kyoto Encyclopedia of Genes and Genomes (KEGG) database will be used to map gene list with KEGG defined bioprocesses. Further, in silico mapping to Simon Foundation Autism Research Initiative (SFARI) data base will delineate their significance in autistic brains.
Neuroimaging- to unravel brain connectivity maps using electroencephalogram (EEG) to understand the cognition and perception
. Mapping brain connectivity in autistic children in India from different cultural and economic backgrounds, will generate a comprehensive demographic study on autism. It will also help us generate a data consortium to bridge the gap between genetic mechanisms of neuropathology to global measures of brain function.
Sangu Muthuraju, Mohamed Rafiqul Islam, Soumya Pati
, Hasnan Jaafar, Jafri Malin Abdullah, and Kamaruddin Mohd. Yusoff, Normobaric hyperoxia treatment prevents early alteration in dopamine level in mice striatum after fluid percussion injury: a biochemical approach. International Journal of Neuroscience, 2014; 00(00): 1–7. ISSN: 0020-7454 print / 1543-5245 online DOI: 10.3109/00207454.2014.961065.
, NorEntan Supeno, Sangu Muthuraju, Raisah Ab. Hadi, Abdul Rahman I Ghani, MD, Fauziah M Idris, MD; Mirjana M Savatic, Jafri M Abdullah, Hasnan Jaafar, MicroRNA profiling Reveals unique miRNA signatures in IGF-1 treated embryonic striatal stem cell fate decisions in striatal neurogenesis in vitro. (Biomed Res Int. 2014; 2014:503162. doi: 10.1155/2014/503162. Epub 2014 Sep 1. PMID: 25254208).
Tee Jong Huat, Amir Ali Khan, Soumya Pati
, Jafri Malin Abdullah & Hasnan Jaafar, IGF-1 enhances cell proliferation and survival during early differentiation of mesenchymal stem cells to neural progenitor-like cells. (BMC Neurosci. 2014 Jul 22; 15:91. doi: 10.1186/1471-2202-15-91. PMID: 25047045).
Sangu Muthuraju, Syed Taha, Soumya Pati
, Mohamed Rafique, Hasnan Jaafar, Jafri Malin Abdullah (2013). Normabaric Hyperoxia Treatment Improved Locomotor Activity of C57BL/6J Mice through Enhancing Dopamine Genes Following Fluid-Percussion Injury in Striatum.
Int J Biomed Sci
.2013 dec 9(4):194-204. PMID: 24711754.
Muthuraju, S., Pati, S
., Rafiqul, M., Abdullah, J.M. and Jaafar, H (2013). Effect of normabaric hyperoxia treatment on neuronal damage following fluid percussion injury in the striatum of mice: A morphological approach. J. Biosci. 38 (1–11).
. PMID: 23385817.
Supeno NE, Pati S*
, Hadi RA, Ghani ARI, Mustafa Z, Abdullah JM, Idris FM, Han X, Jaafar H (2013). IGF-1 Acts as Controlling Switch for Long-term Proliferation and Maintenance of EGF/FGF responsive Striata Neural Stem Cells. (*Co-first authors
Int J Med Sci.
10(5):522-531. Doi:10.7150/ijms.5325. PMID: 23532711.
Sangu Muthuraju, Soumya Pati
, Mohammad Rafiqul, Jafri Malin Abdullah, Hasnan Jaafar (2012). IntelliCage provides voluntary exercise and an enriched environment, improving locomotive activity in mice following fluid percussion injury.
Muthuraju, S., Maiti, P., Pati, S
., Solanki, P., Sharma, A.K., Singh, S.B., Prasad, D., Ilavazhagan, G (2011). Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia.
Eur J Pharmacol
. 672(1-3):96-105. PMID: 21924263.
Muthuraju, S., Maiti, P., Solanki, P., Sharma, A.K., Pati, S
., Singh, S.B., Prasad, D., Ilavazhagan, G (2011). Possible role of cholinesterase inhibitors on memory consolidation following hypobaric hypoxia of rats.
Int J Neurosci
. 121(5):279-88. PMID: 21348795.
., Kalra, O.P., and Mukhopadhyay, A (2011). Foe turned friend: multiple functional roles attributable to hyper-activating stem cell factor receptor mutant in regeneration of the hematopoietic cell compartment,
, 44(1):10-8. PMID: 21199006.
., Gurudutta, G.U., Kalra, O.P., and Mukhopadhyay, A (2010). The structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): An In silico analysis.
BMC Res Notes
, 3:14. PMID: 20205869.
Sharma, S., Gurudutta, G.U., Satija, N.K., Pati, S
., Afrin, F., Gupta, P., Verma, Y.K., Singh, V.K.,Tripathi, R.P (2006). Stem Cell c-Kit and HOXB4 Genes: Critical Roles and Mechanisms in Self-Renewal, Proliferation, and Differentiation.
Stem Cells Dev
., 15(6): 755-778. PMID: 17253940.
Gurudutta, G.U., Babbar, A.K., Singh, S., Pati, S
., and Sharma, R.K (2001). Evaluation of potential tracer ability of 99m Tc labeled acetylated-LDL for scintigraphy of LDL-scavenger receptor sites of macrophageal origin,
Nucl Med & Biol
, 28, 235-241. PMID: 11323232.
Sangu Muthuraju, Soumya Pati
(2014) Effect of Hypobaric Hypoxia on Cognitive Functions and Potential Therapeutic Agents.
Malays J Med Sci.
Special Issue Neuroscience: 40-44.
National & International Recognition:
2002 Best Poster Presentation
, International Conference, LASTEC Center, Delhi, India
2003 Best Poster Presentation
, 4th annual Symposium on Frontiers in Biomedical Research, University of Delhi.
2010 Best Oral Presenter
, UMT 9th International Symposium on Sustainability Science and Management, University of Malaysia.
2010 DST Fast Track Young Scientist Award
, Ministry of Science and Technology, Govt of India.
International Grants: 2012 - 2014;
Autism Speaks Grant Awardee for Translational Research” in “Integrative System Biology of iPSC-induced Neurons for Identifying Novel Drug Targets” (http://www.autismspeaks.org/science/science-news/autism-speaks-awards-newresearch grants
2011 – Best AOSpine South East Asia Research Grant Awardee
, Co-investigator on the grant: Generation of stem cell-derived intervertebral disc specific lineages by co-culturing neural crest stem cells and mesenchymal stem cells.
2010- Fundamental Research Grant
, Ministry of Education, Co-PI on the grant: Epigenetic Remodeling of Mesenchymal stem cells.
2010-Research and Development seed grant
, University Sains Malaysia
Selected recent oral presentations and posters (2011-2014):
, Li-hua Ma, Xu Han, Cemal Karakas and Mirjana Maletic Savatic. In Silico Mapping of Metabolome Reveals Unique Metabolomic Signatures in Glutamatergic Neurons. (Abstract presented as poster in International Society for Stem Cell Research, June 12-15, Boston, MA, USA).
Invited Oral presenter: Soumya Pati
, Xu Han, Mirjana Maletic-Savatic, Pathway mapping of transcriptome revealed potential neuronal fate discriminators in human embryonic stem cell derived neural progenitors in 6th Annual Congress of Regenerative Medicine & Stem Cell-2013 (RMSC- 2013), Dalian Hi-tech Industrial Zone, LN 116025, China.
Invited Oral presenter: Soumya Pati
. NMR based metabolomic profiling of human embryonic stem cell derived neurons, 2nd World Congress on Cell Science and Stem Cell Research, San Antonio, TX (published as Soumya Pati, Li-hua Ma, Wendy Han, Cemal Karakas and Mirjana Maletic Savatic, J Cell Sci Ther 2012, 3:8).
Best Oral presenter: Soumya Pati
, Nor Entan Supeno, Raisah Ab. Hadi, Jafri Malin Abdullah, Hasnan Jaafar, “Long-term culture of rat embryo derived neural stem cells under conditioned microenvironment: Implications in stem cell fate specifications”. UMT 9th International Symposium on Sustainability Science & Management 2010 (UMTAS 2010), “Towards a Healthier and Sustainable Future” Date: 8th -11th May 2010, Universiti Malaysia Terengganu, Malaysia.
, Sangu Muthuraju, Nor Entan Supeno, Raisah Ab. Hadi, Jafri Malin Abdullah, Hasnan Jaafar. Abstract accepted for Society for Neuroscience, 2011. “Effect of neurotrophins on E18th day rat embryonic striatal stem cell derived neurogenesis; a cellular-to-molecular study (Abstract accepted for poster presentation in Society for Neuroscience, Neuroscience 2011, Washington DC, USA.
Sangu Muthuraju., Soumya Pati
., Govindasamy Ilavazhagan, Jafri Malin Abdullah*. Role of cholinergic neurons in neuroprotection in rats exposed to hypobaric hypoxia. Abstract accepted for Society for Neuroscience, 2011.
Dr. Soumya Pati gained her PhD from the University of Delhi & National Institute of Immunology in the area of Biomedical Sciences during 2009. Following this she joined the Dept.of Neuroscience, School of Medical Sciences, University Sains Malaysia as a postdoctoral fellow. In 2011, she joined Maletic-Savatic Lab, Jan & Dan Duncan Neurological Research Institute, Baylor College of Medicine, Texas, USA to work on “Detection of Novel Biomarkers in Idiopathic Autism Using Integrative System Biology”. Based on her preliminary findings she received one of the prestigious grant award from Autism Speaks foundation as an independent investigator, USA. Dr.Pati’s work has been acclaimed by international societies and published in reputed international journals. With a strong base in neurological disease remodeling, she is currently focussed to investigate altered brain communications related to cognitive abilities in autistic brain and decipher the underlying attenuated molecular mechanism in idiopathic autism. The outcomes of the research may provide novel therapeutic biomarkers relevant to early diagnosis in autism.