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Department of Life Sciences
Koyeli Mapa
Assistant Professor
Department of Life Sciences
School of Natural Sciences
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Education Details
Ph.D. (Biochemistry), Max Planck Research School, Medical faculty, Munich University, Germany (2009)
MBBS, Calcutta Medical College, Calcutta University (2002)
Professional Experience
Assistant Professor, Shiv Nadar University, Dadri, UP, India (2015-present)

Innovative Young Biotechnologists Award (IYBA) Fellow, CSIR-IGIB, Delhi, India (2010-2015)

Fellow of International Max Planck research School, Dresden, Germany (2004-2005)

Junior Research Fellow, IISc, Bangalore, India (2003-2004)

Clinical Intern at Calcutta Medical College and Hospital, Kolkata, India (2001-2002)
Research Interests
Role of molecular chaperones in health and diseases

Stress response pathways in Mitochondria

Study of Mitochondrial dysfunctions in various pathological conditions like myopathies and neurodegenerative disorders
Select Publications
  1. Banerjee R, Gladkova C, Mapa K, Witte G, Mokranjac D. Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein. Elife. 2015 Dec 29;4. pii: e11897. doi: 10.7554/eLife.11897. Impact factor: 9.32

  2. Nagpal S, Tiwari S, Mapa K*, Thukral L*. Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding. PLoS Comput Biol. 2015 Sep 22;11(9):e1004496. (* joint corresponding authors). Impact factor: 4.62

  3. Kumar S, Mapa K, Maiti S. Understanding the effect of LNA and 2´-O methyl modification on the hybridization thermodynamics of miRNA-mRNA pair in the presence and absence of AfPiwi protein. Biochemistry. 2014 Feb 24. Impact factor: 3.42

  4. Sikor M, Mapa K, Voith von Voithenberg L, Mokranjac D, and Lamb DC. Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET. EMBO J. 2013 Apr 26. (2013) 32, 1639 - 1649. Impact factor: 10.0

  5. Agarwala P, Pandey S, Mapa K, Maiti S. G-quadruplex augments translation in 5' Untranslated Region of Transforming Growth Factor β2 (TGFβ2). Biochemistry. 2013 Mar 5;52(9):1528-38. Impact factor: 3.42

  6. Tiwari S, Kumar V, Jayaraj GG, Maiti S, Mapa K*. Unique Structural Modulation of a Non-Native Substrate by Cochaperone DnaJ. Biochemistry. 2013 Feb 12;52(6):1011-8. (*corresponding author). Impact factor: 3.42

  7. Mapa K*, Tiwari S, Kumar V, Jayaraj GG and Maiti S. Information encoded in non-native states drives substrate-chaperone pairing. Structure 2012 Sep 5;20(9):1562-73. (*corresponding author). Impact factor: 6.33

  8. Kumar S, Bose D, Suryawanshi H, Sabharwal H, Mapa K, Maiti S. Specificity of RSG-1.2 peptide binding to RRE-IIB RNA element of HIV-1 over Rev peptide is mainly enthalpic in origin. PLoS One. 2011;6(8):e23300. Epub 2011 Aug 10. Impact factor: 4.0

  9. Popov-Celeketic D, Waegemann K, Mapa K, Neupert W and Mokranjac D. Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex. EMBO Rep. 2011 Jun;12(6):542-8. Impact factor: 7.8

  10. Mapa K, Sikor M, Kudryavstev V, Waegemann K, Kalinin S, Seidel CAM, Neupert W, Lamb DC and Mokranjac D.The Conformational dynamics of the mitochondrial Hsp70 chaperone. Mol Cell. 2010 Apr 9;38(1):89-100. Impact factor: 13.5

  11. Blamowska M, Sichting M, Mapa K, Mokranjac D, Neupert W and Hell K. ATPase Domain and Interdomain Linker Play a Key Role in Aggregation of Mitochondrial Hsp70 Chaperone Ssc1. J Biol Chem. 2010 Feb 12;285(7):4423-31. Impact factor: 5.5

  12. Mokranjac D, Sichting M, Popov-Celeketic D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W. Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria. Mol Biol Cell. 2009 Mar; 20(5):1400-7. Impact factor: 5.5

  13. Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic DA, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D. Interaction of tim23 with tim50 is essential for protein translocation by the mitochondrial tim23 complex. J Biol Chem. 2009 Feb 20;284(8):4865-72. Impact factor: 5.5

  14. Popov-Celeketić D*, Mapa K*, Neupert W, Mokranjac D.Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria. EMBO J. 2008 May 21;27(10):1469-80. (*Equally contributing first authors). Impact factor: 8.0

  15. Dhar D*, Mapa K.*, Pudi R., Srinivasan P., Bodhinathan K., Das S. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. Arch Virol. 2006 Mar;151(3) :509-24. (*Equally contributing first authors). Impact factor: 1.8

  16. Bhattacharyya S., Mapa K., Prabhavathi S., Sudhamani SR., Menon PK., John KP. ,Shivaram C., Amarnath S., Das S. Phylogenetic conservation of the stem-loop III structure of the 5' untranslated region of Hepatitis C virus RNA among natural variants in samples collected from Southern India. Arch Virol. 2004 May; 149(5): 1015-26. Impact factor: 1.8
National and International Recognition
Innovative Young Biotechnologist Award (IYBA) from Department of Biotechnology (DBT), India, 2009
Passed the Doctoral degree examination with ‘Summa cum laude’, the highest passing grade from Medical Faculty, Munich University (LMU), Germany, 2009

EMBO-FEBS Youth Travel grant, 2006

Fellowship from International Max Planck research school (IMPRS) for pursuing doctoral research in Molecular and Cellular life sciences, Munich, Germany, 2005

Fellowship from International Max Planck research school (IMPRS) for pursuing doctoral research in Cell Biology and Bioengineering , Dresden, Germany, 2004
Executive Summary
Koyeli obtained an MBBS from Calcutta Medical College following which she moved from medicine to basic research. After a brief stint at the Indian Institute of Science (IISc), Bangalore, she moved to Germany for her doctoral studies. Subsequently, she graduated with “summa cum laude” from the Medical faculty of Munich University (LMU), Germany, as a fellow of the prestigious International Max Planck Research School (IMPRS). Back in India, she received the Innovative Young Biotechnologist Award (IYBA) from the Department of Biotechnology, Government of India and worked as an IYBA fellow in the CSIR-Institute of Genomics and Integrative Biology, Delhi, before joining Shiv Nadar University. Koyeli is interested in delineating the role of molecular chaperones in heath and misfolding-induced diseases such as neurodegenerative disorders. Simultaneously, she is interested in deciphering the stress response pathways of mitochondria, the cellular power-house and how mitochondrial dysfunction happens during various pathological conditions. Koyeli has published several research papers in various journals of high international repute.
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