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Department of Life Sciences
Seema Sehrawat
Associate Professor,
Department of Life Sciences,
School of Natural Sciences
Email Contact: and
Education Details
PhD in Molecular Biology, Indian Institute of Science, Bangalore.
Masters in Biotechnology, M S University, Baroda.
Bachelors in Biochemistry, Sri Venkateswara College, Delhi University.
Professional Experience:
2012-present, Associate Professor, Shiv Nadar University, India

2016-present, Visiting Associate Professor, Laboratory for Nanomedicine, Brigham and Women’s Hospital, Harvard Medical School Affiliated to Harvard-MIT, Health Sciences and Technology, Boston, MA, USA

2016-present, HBX-Harvard Business School, Pre-MBA Course-CORe: Credential of Readiness: Business Analytics; Economics for Managers; Financial Accounting (Enrolled)

2016-present, The Regulatory Affairs Essentials Certificate Program, University of California, San Diego Extension, USA (Enrolled)

2015-2016, Visiting Faculty, Laboratory for Nanomedicine, Harvard Medical School, Boston, MA, USA

2009-2012, Research Fellow, Center for Excellence in Vascular Biology, Harvard Medical School, Boston MA, USA

2004-2009, Post-Doctoral Fellow, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Research Grants:
  1. Bio-CARe AWARD, Department of Biotechnology, Government of India

    Total Budget-50 lakhs (~80,000 dollars) as Principal Investigator.

    Functional dissection of cAMP regulated AKAP9 in Vascular dysfunction: Strategy for treatment of Breast Cancer, 2014-2017

  2. Multidisciplinary Collaborative grant with Dr. Debopam Acharya (PI), Department of Computer Science, SNU; IIIT New Delhi and IGDTUW. Funded by Information Technology Research Academy ITRA, Department of Electronics and Information Technology, Govt. Of India (DeitY)

    Total Budget ~ 2.6 crores (~400,000 dollars) as one of the Co-Investigators.

    HumanSense: Towards context aware sensing, inference and actuation for applications in Energy and Healthcare, 2013-16
Research Interests:

There are two major areas of research in the lab:
  1. Cerebral Vascular Biology
    Our aim is to explore the mechanistic details of Vascular Dysfunction in Brain Glioma with particular focus on the following areas of research:
    • Analyzing the role of Kruppel like factors in Neural microenvironment and Glioma progression
    • Role of AKAPs in Vascular Remodeling at the Brain Tumor Barrier
    • Detection of Novel Signature molecules from the analysis of Brain Proteome

  2. Breast Cancer Vascular Remodeling
    We study the molecules involved in Vascular Dysfunction in Breast cancer with particular focus on the following areas of research:
    • Understanding various signaling molecules regulating Kruppel like factors in Breast Cancer progression
    • Role of AKAPs in Vascular Dysfunction in Breast Cancer
    • Bioengineering and Genome Editing: Precision genome manipulation of cAMP modulated genes utilizing the Genome editing techniques like Transcription activator-like effector nucleases (TAL) and Clustered regularly interspaced palindromic repeat (CRISPR) systems.

    The detailed analysis of molecular signaling will lead to development of novel therapeutics. The emphasis is on the following areas of study:
    • Nanovehicles for drug delivery, therapeutics and human health
    • Zebrafish and mice in vivo model systems
National & International Recognition:
The research work in the area of Vascular Biology has been appreciated both nationally and internationally. Publications in high impact journals like Nature Communications, Blood, PNAS, Molecular Biology of the Cell, Journal of Immunology, Biochemical Journal, Stem Cell Reports, Gene, Organic and Biomolecular Chemistry.
  • Bio-CARe AWARD, Department of Biotechnology, Government of India, 2014-2017

  • Talwar Immunology Foundation Award, 2013.

  • International Travel Award, Department of Science and Technology, India 2013.

  • Senior Research fellowship by Council for Scientific and Industrial Research, Govt. of India through a highly competitive nation-wide examination, 2001.

  • Recipient of ECIS Mini Grant by Applied Biophysics. The ECIS mini-grant is aimed at early career scientists who are applying for their first RO1 grant. For a researcher wanting to use ECIS technology to achieve their research goals, Applied BioPhysics provides an ECIS instrument, ECIS arrays, and consultation in order to generate preliminary data to support the applicants RO1 proposal, 2011.

  • Awarded the Tata Fund for Protein Homology modelling programme for beginners at EMBL, Germany, 1997.

  • Junior Research fellowship by Council for Scientific and Industrial Research, Govt. of India through a highly competitive nation-wide examination (1996-1998).

  • Selected for the highly ranked Cambridge Nehru Scholarship (Trinity College). Up to eight scholarships are offered annually in collaboration with the Nehru Trust for Cambridge University for students from India, 1996, Did not Awail.

Select Publications:
  1. Yamicia Connor, Sarah Tekleab, Shyama Nandakumar, Cherelle Walls, Yonatan Tekleabr, Amjad Husain, Or Gadish, Venkata Sabbisetti, Shelley Kaushik, Seema Sehrawat, Ashish Kulkarni, Harold Dvorak, Elazer Edelman, Bruce Zetter, Shiladitya Sengupta (2015). Physical nanoscale conduits-mediated communication between tumor cells and endothelium enables a metastatic hijack. Nature Communications, December 16; 6: 8671. [Impact factor 11.47].

  2. Kalai Mangai Muthukumarasamy, Kishor L Handore, Dipti N Kakade, Madhuri Vikas Shinde, Shashi Ranjan, Naveen Kumar, Seema Sehrawat, Chetana Sachidanandan and D SRINIVASA REDDY (2015). Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays. Org. Biomol. Chem., October 20 [Impact factor 3.6].

  3. Raj N, Helen A, Manoj N, Harish G, Thomas V, Singh S, Sehrawat S, Seth S, Nair AS, Grover A, Dhar PK (2015). In silico study of peptide inhibitors against BACE 1. Systems and Synthetic Biology, Jun; 9(1-2):67-72.

  4. Vipin Thomas, Navya Raj, Deepthi Varughese, Naveen Kumar, Sehrawat S, Abhinav Grover, Shailja Singh, Pawan K. Dhar, Achuthsankar S. Nair (2015). Predicting stable functional peptides from the intergenic space of E. Coli. Systems and Synthetic Biology, May.

  5. Swati Garg, Shalini Agarwal, Surbhi Dabral, Naveen Kumar, Sehrawat S, Shailja Singh (2015). Visualization and quantification of Plasmodium falciparum intraerythrocytic merozoites. Systems and Synthetic Biology, April.

  6. Lakshmi Kannan, Katalin Kis-Toth, Kazuhisa Yoshiya, Sehrawat S, Jurandir J. Dalle Lucca, To-Ha Thai, Tanya Mayadas, George C. Tsokos (2013). R-spondin3 protects intestinal tissue from ischemia/reperfusion-induced injury by tightening endothelial cell junctions and preventing vascular leakage. Proc Natl Acad Sci U S A. 2013 Aug 27;110 (35):14348-53 [Impact factor 9.73].

  7. William James Adams, Yuzhi Zhang, Jennifer Cloutier, Pranati Kuchimanchi, Gail Newton, Sehrawat S, William Cameron Aird, Tanya Mayadas Norton, Francis William Luscinskas, and Guillermo García-Cardeña (2013). Generation and Specification of Functional Human Vascular Endothelium Derived from Induced Pluripotent Stem Cells. Published in the inaugural Issue of “Stem Cell Reports” Vol. 1, 105–113, August 6. [Impact factor 5.72].

  8. Sehrawat S, Ernandez T, Cullere X , Komarova Y, Mayadas TN. (2011). AKAP9 regulation of microtubule dynamics promotes Epac1 induced endothelial integrin adhesion at cell-cell contacts. Blood, 117(2):708-18. [Impact factor: 10.558]

  9. Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW. (2008). p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood. 112(7):2770-9. [Impact factor: 10.558]

  10. Sehrawat S, Cullere X, Patel S, Italiano J Jr, Mayadas TN. (2008). Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell. 19(3):1261-70. [Impact factor:6]

  11. Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW. (2007). Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent. J Immunol. 178(9):5879-87. [Impact factor: 6]

  12. Sehrawat S, and Gopinathan, K. P. (2002). Temporal expression profile of late gene expression 4 from Bombyx mori nucleopolyhedrosis virus. Gene 294, 67-75. [Impact factor: 2.34]

  13. Sehrawat S, Srinivasan, N. and Gopinathan, K. P. (2002). Functional characterization and structural modeling of late gene expression factor 4 from Bombyx mori nucleopolyhedrosis virus. Biochem. J. 368, 159-169. [Impact factor: 5]

  14. Acharya, Asha, Satyanarayana S, Sehrawat S, Sehgal D, Gopinathan, K. P. (2002) Bombyx mori nucleopolyhedrovirus: Molecular biology and biotechnological applications for large-scale synthesis of recombinant proteins. Current Science. 83 (04). [Impact factor: 0.8]
Major Presentations, Conferences and Workshops:
  1. Seema Sehrawat. Invited Speaker, BiTERM, International Conference on Biomaterials, Biodiagnostics, Tissue Engineering, Drug Delivery and Regenerative Medicine, April 15-17, 2016, Center for Biomedical Engineering, IIT, New Delhi, India

  2. Rahul Majethia, Varun Mishra, Prasad Pathak, Divya Lohani, Debopam Acharya and Seema Sehrawat. Contextual Sensitivity of the Ambient Temperature Sensor in Smartphones. Seventh International Conference on COMmunication Systems and NETworkS (COMSNETS 2015), Jan 6-10, Bangalore, India. Full Conference Paper Accepted

  3. Seema Sehrawat. Role of AKAP9 in Breast cancer, Harvard-MIT Health Sciences and Technology, October 23, 2015, Cambridge, MA.

  4. Seema Sehrawat. Third Annual Workshop on "Micro- and Nanotechnologies for Medicine: Emerging Frontiers and Applications", Harvard-MIT Health Sciences and Technology, July 27–July 31, 2015, Cambridge, MA.

  5. Seema Sehrawat. 250th American Chemical Society Meeting, INNOVATION from Discovery to Application, August 16-20, 2015, Boston, MA.

  6. Alcaide P, Newton G, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW. (2008). p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. FASEB Journal (Meeting Abstract Supplement), 2007; 329.10

  7. Sehrawat S, Cullere X, Patel S, Italiano J Jr, Mayadas TN. (2008). Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. FASEB Journal (Meeting Abstract Supplement), 2008; 22; 329.

  8. Kumar Naveen, Remya Krishnan, Pawan K Dhar, Seema Sehrawat. Non-coding DNA derived Anti-cancer peptides tagged to DARPins: Novel Immuno-modulatory Scaffold therapeutics for effective treatment of Breast Cancer. International conference on Proteomics from Discovery to Function, Dec 7-9, 2014, IIT Mumbai, India. Journal of Protein and Proteomics (Meeting Abstract Supplement).

  9. Naveen Kumar, Swapnil Shukla, Seema Sehrawat, Bimlesh Lochab. Synthetic Phenolics conjugated with Graphene Oxide: Proposing a novel Nanotherapeutic approach for treatment of Breast Cancer. Indo-US Conference on Synthetic and Systems Biology, November 9-12, 2014, New Delhi.

  10. Seema Sehrawat*, Deepthi Varughese*, Rajni Madan, Naveen Kumar, Shailja Singh, Vipin Thomas, Mukta Joshi, Pawan K Dhar. Non-coding DNA derived peptides tagged to DARpins: Proposing a novel Endothelium mediated approach for the treatment of Breast Cancer. Presented research work as an important delegate at the Drug Discovery Congress organized by OXFORD GLOBAL, October 21-22, 2014, Boston Harbor Hotel, Boston, USA.

  11. Seema Sehrawat. Identification and Characterization of Biomarkers for Breast Cancer involved in regulation of Endothelial Barrier function. Global Biomarkers Consortium - Clinical Approaches to Targeted Technologies”, October 4-6, 2013, Boston, MA, USA.
Executive Summary:
Dr. Seema Sehrawat is a Vascular Biologist trained at the prestigious Center for Vascular Biology, Harvard Medical School, USA with a strong background in primary Endothelial cell culture, ECIS based Vascular Permeability Analysis, Live Cell Imaging, Cell Migration, 2D and 3D Angiogenesis. Her primary area of research interest is Vascular Dysfunction in Breast Cancer and Neuro-Oncology. She has successfully handled independent research grant on Breast Cancer therapeutics as a lead Investigator and is currently involved in a research grant on Cerebral Edema. Her future interests include Data Science Research, Machine Learning and Big Data Management for Acceleration of Biological Research.
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