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SCHOOL OF NATURAL SCIENCES
NATURAL SCIENCES
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Faculty
Department of Life Sciences
Seema Sehrawat
Associate Professor,
Department of Life Sciences,
School of Natural Sciences
Email Contact: and
Education Details
PhD, Indian Institute of Science, Bangalore
MS, Biotechnology, M S University, Baroda
BS (Hons), Biochemistry, Sri Venkateswara College, Delhi University
Professional Experience:
2012-present, Associate Professor, Brain Metastasis and NeuroVascular Disease Modeling Lab, Shiv Nadar University, India

2017-present, Professor (Visiting), Laboratory for Translational Medicine, Division of Biomedical Engineering, Brigham and Women’s Hospital, Harvard Medical School Affiliated to Harvard-MIT, Health Sciences and Technology, Boston, MA, USA ()

2015-2017, Associate Professor (Visiting), Laboratory for Nanomedicine, Division of Biomedical Engineering, Brigham and Women’s Hospital, Harvard Medical School Affiliated to Harvard-MIT, Health Sciences and Technology, Boston, MA, USA

2016, Pre-MBA Course-CORe: Credential of Readiness: Emphasis on Business Analytics; Economics for Managers; Financial Accounting, HBX-Harvard Business School, Boston, MA, USA

2016, Preliminary Regulatory Affairs Essentials Certificate Program, University of California San Diego, School of Extended Studies and Public Program, USA

2009-2012, Research Fellow, Role of cAMP/PKA/AKAP9 in Endothelial Cell Permeability and Angiogenesis using Microfluidics based Chips, Platforms & Cell Signaling Analysis for BioMedical Applications, Center for Excellence in Vascular Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston MA, USA

2004-2009, Post-Doctoral Fellow, Biomedical Engineering and Vascular Biology-cAMP-Epac1 dependent Endothelial Barrier Regulation & Microtubule Dynamics, Microfluidics based Chips, Platforms & Cell Signaling Analysis, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Research Grants:
  1. Bio-CARe AWARD, Department of Biotechnology, Government of India

    Total Budget-50 lakhs (~80,000 dollars) as Principal Investigator.

    Functional dissection of cAMP regulated AKAP9 in Vascular dysfunction: Strategy for treatment of Breast Cancer, 2014-2017, Extendable 2017-2019 with additional budget (3+2 years).

  2. Multidisciplinary Collaborative grant with Dr. Debopam Acharya (PI), Department of Computer Science, SNU; IIIT New Delhi and IGDTUW. Funded by Information Technology Research Academy ITRA, Department of Electronics and Information Technology, Govt. Of India (DeitY)

    Total Budget ~ 2.6 crores (~400,000 dollars) as one of the Co-Investigators.

    HumanSense: Towards context aware sensing, inference and actuation for applications in Energy and Healthcare, 2013-16
Research Interests:
BIOMEDICAL ENGINEERING

BRAIN METASTASIS AND NEUROVASCULAR DISEASE MODELING LAB
  • Combination Therapy for Breast Cancer associated Brain Metastasis and Tumor Angiogenesis

  • Small molecule inhibitors, siRNA, miRNA and CRISPR/CAS9 conjugated Nanomedicine based therapy: In vivo mimic Brain Metastasis and Neurovascular Disease models in 3D using Impedance Sensing based Microfluidic Platforms and Chips

  • Brain Connectome and Neural Stem cell based therapy

  • 3D Bioprinted Platforms and devices for CRISPR/CAS9 based Genome Editing in Brain Stroke treatment

  • Proteomic based approach to identify novel targets for Cancer Immunotherapy

Graduate Students

Naveen Kumar
Novel Molecules regulating cAMP Signaling: Nanomedicine Based Therapy for Breast Cancer associated Brain Metastasis (2013-2017).

Peeyush Prasad
Neurovascular in vivo mimic disease model and immunotherapy based approach for Brain Metastasis Therapy (2016-2020).

Undergraduate Students

Shivani Shirbate
Novel Silencing RNA conjugated Nanovehicles for targeting Breast Cancer associated Brain Metastasis.

Eshna Jash
Role of Novel Cilostazol derivatives in maintaining Neuroplasticity: Functionalized Nanoparticle based Theranostics.
National & International Recognition:
The research work in the area of Brain Metastasis and NeuroVascular Disease Modeling has been appreciated both nationally and internationally. Publications in high impact journals like Nature Communications, Blood, PNAS, Molecular Biology of the Cell, Journal of Immunology, Biochemical Journal, Stem Cells Reports, Molecular and Cellular Biochemistry, Gene and Organic and Biomolecular Chemistry.
  • Bio-CARe AWARD, Department of Biotechnology, Government of India, 2014-2017

  • Talwar Immunology Foundation Award, 2013.

  • International Travel Award, Department of Science and Technology, India 2013.

  • Senior Research fellowship by Council for Scientific and Industrial Research, Govt. of India through a highly competitive nation-wide examination, 2001.

  • Recipient of ECIS Mini Grant by Applied Biophysics. The ECIS mini-grant is aimed at early career scientists who are applying for their first RO1 grant. For a researcher wanting to use ECIS technology to achieve their research goals, Applied BioPhysics provides an ECIS instrument, ECIS arrays, and consultation in order to generate preliminary data to support the applicants RO1 proposal, 2011.

  • Awarded the Tata Fund for Protein Homology modelling programme for beginners at EMBL, Germany, 1997.

  • Junior Research fellowship by Council for Scientific and Industrial Research, Govt. of India through a highly competitive nation-wide examination (1996-1998).

  • Selected for the highly ranked Cambridge Nehru Scholarship (Trinity College). Up to eight scholarships are offered annually in collaboration with the Nehru Trust for Cambridge University for students from India, 1996, Did not Awail.

Select Publications:
  1. Naveen Kumarǂ, Sonal Guptaǂ, Surbhi Dabral, Shailja Singh*, Seema Sehrawat* (2017). Role of Exchange Protein directly activated by cAMP (EPAC 1) in Breast cancer cell migration and Apoptosis. Molecular and Cellular Biochemistry. Feb 16. doi: 10.1007/s11010-017-2959-3

  2. Naveen Kumarǂ, Santanu Hatiǂ, Parthapratim Munshi, Subhabrata Sen, Seema Sehrawat*, Shailja Singh* (2017). A Novel Spiroindoline targets Cell cycle and Migration via modulation of Microtubule Cytoskeleton. Molecular and Cellular Biochemistry. Feb 17. doi: 10.1007/s11010-016-2932-6.

  3. Kalai Mangai Muthukumarasamy, Kishor L Handore, Dipti N Kakade, Madhuri Vikas Shinde, Shashi Ranjan, Naveen Kumar, Seema Sehrawat, Chetana Sachidanandan and D SRINIVASA REDDY (2016). Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays. Org. Biomol. Chem. Feb 7;14(5):1569-78

  4. Yamicia Connor, Sarah Tekleab, Shyama Nandakumar, Cherelle Walls, Yonatan Tekleabr, Amjad Husain, Or Gadish, Venkata Sabbisetti, Shelley Kaushik, Seema Sehrawat, Ashish Kulkarni, Harold Dvorak, Elazer Edelman, Bruce Zetter, Shiladitya Sengupta (2015). Physical nanoscale conduits-mediated communication between tumor cells and endothelium enables a metastatic hijack. Nature Communications, December 16; 6: 8671. [Impact factor 11.47].

  5. Raj N, Helen A, Manoj N, Harish G, Thomas V, Singh S, Sehrawat S, Seth S, Nair AS, Grover A, Dhar PK (2015). In silico study of peptide inhibitors against BACE 1. Systems and Synthetic Biology, Jun; 9(1-2):67-72.

  6. Vipin Thomas, Navya Raj, Deepthi Varughese, Naveen Kumar, Sehrawat S, Abhinav Grover, Shailja Singh, Pawan K. Dhar, Achuthsankar S. Nair (2015). Predicting stable functional peptides from the intergenic space of E. Coli. Systems and Synthetic Biology, Dec; 9 (4):135-140

  7. Lakshmi Kannan, Katalin Kis-Toth, Kazuhisa Yoshiya, Sehrawat S, Jurandir J. Dalle Lucca, To-Ha Thai, Tanya Mayadas, George C. Tsokos (2013). R-spondin3 protects intestinal tissue from ischemia/reperfusion-induced injury by tightening endothelial cell junctions and preventing vascular leakage. Proc Natl Acad Sci U S A. 2013 Aug 27;110 (35):14348-53 [Impact factor 9.73].

  8. William James Adams, Yuzhi Zhang, Jennifer Cloutier, Pranati Kuchimanchi, Gail Newton, Sehrawat S, William Cameron Aird, Tanya Mayadas Norton, Francis William Luscinskas, and Guillermo García-Cardeña (2013). Generation and Specification of Functional Human Vascular Endothelium Derived from Induced Pluripotent Stem Cells. Published in the inaugural Issue of “Stem Cell Reports” Vol. 1, 105–113, August 6. [Impact factor 7.02].

  9. Sehrawat S, Ernandez T, Cullere X , Komarova Y, Mayadas TN. (2011). AKAP9 regulation of microtubule dynamics promotes Epac1 induced endothelial integrin adhesion at cell-cell contacts. Blood, 117(2):708-18. [Impact factor: 11.84]

  10. Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW. (2008). p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood. 112(7):2770-9. [Impact factor: 11.84]

  11. Sehrawat S, Cullere X, Patel S, Italiano J Jr, Mayadas TN. (2008). Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell. 19(3):1261-70. [Impact factor: 5]

  12. Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW. (2007). Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent. J Immunol. 178(9):5879-87. [Impact factor: 5]

  13. Sehrawat S, and Gopinathan, K. P. (2002). Temporal expression profile of late gene expression 4 from Bombyx mori nucleopolyhedrosis virus. Gene 294, 67-75. [Impact factor: 2.34]

  14. Sehrawat S, Srinivasan, N. and Gopinathan, K. P. (2002). Functional characterization and structural modeling of late gene expression factor 4 from Bombyx mori nucleopolyhedrosis virus. Biochem. J. 368, 159-169. [Impact factor: 5]
Major Presentations, Conferences and Workshops:
  1. Seema Sehrawat. Invited Speaker, BiTERM, International Conference on Biomaterials, Biodiagnostics, Tissue Engineering, Drug Delivery and Regenerative Medicine, April 15-17, 2016, Center for Biomedical Engineering, IIT, New Delhi, India

  2. Rahul Majethia, Varun Mishra, Prasad Pathak, Divya Lohani, Debopam Acharya and Seema Sehrawat. Contextual Sensitivity of the Ambient Temperature Sensor in Smartphones. Seventh International Conference on COMmunication Systems and NETworkS (COMSNETS 2015), Jan 6-10, Bangalore, India. Full Conference Paper Accepted ().

  3. Seema Sehrawat. Role of AKAP9 in Breast cancer, Harvard-MIT Health Sciences and Technology, October 23, 2015, Cambridge, MA.

  4. Seema Sehrawat. Third Annual Workshop on "Micro- and Nanotechnologies for Medicine: Emerging Frontiers and Applications", Harvard-MIT Health Sciences and Technology, July 27–July 31, 2015, Cambridge, MA.

  5. Seema Sehrawat. 250th American Chemical Society Meeting, INNOVATION from Discovery to Application, August 16-20, 2015, Boston, MA.

  6. Alcaide P, Newton G, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW. (2008). p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. FASEB Journal (Meeting Abstract Supplement), 2007; 329.10

  7. Sehrawat S, Cullere X, Patel S, Italiano J Jr, Mayadas TN. (2008). Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. FASEB Journal (Meeting Abstract Supplement), 2008; 22; 329.

  8. Kumar Naveen, Remya Krishnan, Pawan K Dhar, Seema Sehrawat. Non-coding DNA derived Anti-cancer peptides tagged to DARPins: Novel Immuno-modulatory Scaffold therapeutics for effective treatment of Breast Cancer. International conference on Proteomics from Discovery to Function, Dec 7-9, 2014, IIT Mumbai, India. Journal of Protein and Proteomics (Meeting Abstract Supplement).

  9. Naveen Kumar, Swapnil Shukla, Seema Sehrawat, Bimlesh Lochab. Synthetic Phenolics conjugated with Graphene Oxide: Proposing a novel Nanotherapeutic approach for treatment of Breast Cancer. Indo-US Conference on Synthetic and Systems Biology, November 9-12, 2014, New Delhi.

  10. Seema Sehrawat*, Deepthi Varughese*, Rajni Madan, Naveen Kumar, Shailja Singh, Vipin Thomas, Mukta Joshi, Pawan K Dhar. Non-coding DNA derived peptides tagged to DARpins: Proposing a novel Endothelium mediated approach for the treatment of Breast Cancer. Presented research work as an important delegate at the Drug Discovery Congress organized by OXFORD GLOBAL, October 21-22, 2014, Boston Harbor Hotel, Boston, USA.

  11. Seema Sehrawat. Identification and Characterization of Biomarkers for Breast Cancer involved in regulation of Endothelial Barrier function. Global Biomarkers Consortium - Clinical Approaches to Targeted Technologies”, October 4-6, 2013, Boston, MA, USA.

Executive Summary:
Dr. Seema Sehrawat is a Senior Scientist and Associate professor with 10 years of research experience from Harvard Medical School, Boston, MA, USA with research focus in Biomedical Engineering. She is a Professor (Visiting) at the Laboratory for Translational Medicine, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, affiliated to Harvard Health Science and Technology, HST-MIT, Boston, MA, USA. She has published her research work in high impact journals like Nature Communications, Blood, Proceedings of the National Academy of Sciences, Molecular Biology of the Cell, Journal of Immunology, Biochemical Journal, Stem Cells Reports, Molecular and Cellular Biochemistry, Gene and Organic and Biomolecular Chemistry and has obtained independent research funding and grants. Her graduate research work at IISc, Bangalore focussed on Gene Therapy Vehicles for Biomedical Applications. She is a Scientific Advisor at Sporos Therapeutics, a biotechnology company focused on innovative futuristic medicines for solving unmet medical needs. The company focus is centered on the development of Best-in-class approaches to solve the challenges associated with Vaccine Delivery, Next Generation Adjuvants and Cancer BioTherapeutics.
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