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Department of Chemistry
Ram Sagar Misra
Assistant Professor,
Department of Chemistry,
School of Natural Sciences
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Education Details
PhD- Central Drug Research Institute (CDRI) Lucknow, India (2006)     
(Organic Synthesis, Medicinal Chemistry, Natural Product Chemistry)

MSc- University of Lucknow, India (2001) 
(Chemistry with specialization in Organic Chemistry, 1st Division)

BSc- University of Lucknow, India (1998)

(Chemistry, Zoology and Botany, 1st Division)
Academic Profile
  1. Assistant Professor (2012- present), in Chemistry, School of Natural Sciences, Shiv Nadar University, India.
  2. Senior Postdoctoral Research Fellow (2008 - 2012), in Department of Chemistry, Chemistry Research Laboratory, University of Oxford, United Kingdom.
  3. Postdoctoral Research Fellow (2007 - 2008), in Department of Chemistry, Seoul National University, South Korea.
  4. Research Associate (2006 - 2007), in Department of Chemistry, Indian Institute of Technology, Kanpur (IITK) India.
Research Interests
  1. Design and synthesis diversified bioactive small molecules and their application in chemical biology and medicinal chemistry.
  2. Investigation of novel reaction pathways and development of new synthetic reagents/pathways in organic synthesis.
  3. Synthesis of Heterocyles and imino-sugars on the concept of Diversity Oriented Synthesis and Fragment Based Drug Design.
  4. Synthetic Carbohydrate chemistry and new methodology on sugar molecules.
  5. Synthesis of stereochemically pure biomarkers from carbohydrate precursors.
  6. Sugar signaling in living system, Peptide chemistry and preparation of glycoconjugates.
Select Publications
  1. Glycal Derived δ-Hydroxy α,β-unsaturated aldehydes (Perlin aldehydes): A Versatile Building Block in Organic Synthesis. L. V. R. Reddy, Vikas Kumar, Ram Sagar, and Arun K. Shaw Chem. Rev. 2013, DOI: 10.1021/ cr200016m [IF 40.12]

  2. Inhibition of SnRK1 by metabolites: Tissue-dependent effects and cooperative inhibition by glucose 1-phosphate in combination with trehalose 6-phosphate. C. Nunes, Lucia F. Primavesi, Mitul K. Patel, E. Martinez-Barajas, S. J. Powers, Ram Sagar, P. S. Fevereiro, Benjamin G. Davis, Matthew J. Paul Plant Physiol. Biochem. 2013, 63, 89-98. [IF 2.84]

  3. Conformational Effects in Sugar Ions: Spectroscopic Investigations in the Gas Phase and in Solution. Ram Sagar, Svemir Rudic, et al John P Simons and Benjamin G. Davis. Chem Sci. 2012, 3, 2307-2313.[IF 7.52]

  4. Diastereoselective Synthesis of Polycyclic Acetal-Fused Pyrano[3,2-c]pyran-5(2H)-one derivatives. Ram Sagar, Jongmin Park, Minseob Koh and Seung Bum Park. J. Org. Chem. 2009, 74, 2171-2174. [IF 4.00]

  5. Stereoselective synthesis of safingol and its natural stereoisomer from D-glycals. Hariprasad Kokatala, Ram Sagar and Yashvant D. Vankar, Tetrahedron Lett. 2008, 49, 4728-4730. [IF 2.61]

  6. Facile and efficient synthesis of carbohybrids as stereodivergent drug like small molecules. Ram Sagar and Seung Bum Park. J. Org. Chem. 2008, 73, 3270-3273. [IF 4.00]

  7. C-3 Alkyl/Arylalkyl-2,3-dideoxy Hex-2-enopyranosides as Antitubercular Agents: Synthesis, Biological Evaluation, and QSAR Study. Mohammad Saquib, Manish K. Gupta, Ram Sagar, Yenamandra S. Prabhakar, Arun K. Shaw et al. J. Med. Chem. 2007, 50, 2942-2950. [IF 5.20]

  8. A consecutive approach towards the stereoselective synthesis of trisubstituted THF domains. Ram Sagar, L.Vijaya Raghava Reddy, Mohammad Saquib, Brijesh Kumar and Arun K. Shaw, Tetrahedron: Asymmetry 2006, 17, 3294-3299.[IF 2.48]

  9. CP-MLR directed QSAR studies on the antimycobacterial activity of functionalized alkenols-topological descriptors in modeling the activity. Manish K. Gupta, Ram Sagar, Arun K. Shaw and Yenamandra S. Prabhakar, Bioorg. Med. Chem. 2005, 13, 343-351. [IF 2.97]

  10. A Substrate controlled, very high diastereoselective Mortia-Baylis-Hillman reaction: a remote activation on the diastereofacial selectivity in synthesis of C-3-branched deoxysugars. Ram Sagar, C. S. Pant and R. Pathak and Arun K. Shaw, Tetrahedron 2004, 60, 11399-11406. [IF 2.98]

  11. Reinvestigation of the mercuration-demercuration reaction on alkylated glycals: an improved method for the preparation of 2,3-dideoxy-α,β-unsaturated carbohydrate enals. Ram Sagar, Rashmi Pathak and Arun K. Shaw, Carbohydr. Res. 2004, 339, 2031-2035. [IF 2.33]

  1. Modification of trehalose-6-phosphate in plants. Ram Sagar, Lucia F. Primevessi, Matthew J. Paul and Benjamin G. Davis. PCT Patent 2012 (PCT/GB12/050891).

  2. Metabolic Intervention in plant T6P Metabolism. Ram Sagar, Lucia F. Primevessi, Matthew J. Paul, Mitul K. Patel, Conor S. Barry and Benjamin G. Davis. UK Patent  2011 (No. 01107031.5) 26.04.2011

  3. C-3-alkyl and arylalkyl substituted 2,3-dideoxy glucopyranosides as potential anti-tubercular agents and a process for preparation thereof. Ram Sagar, Mohd Saquib, Arun K. Shaw, Anil N. Gaikwad, Sudhir K Sinha, Anil Srivastava, Vinita Chaturvedi, Manju Y. K. Ranjana Srivastava and B. S. Srivastava. Indian Patent (No. 0533DEL2006) 28.02.2006 (Ref. No. 0210NF2005).
Teaching Experience
  1. Taught organic chemistry upto class of fifty undergraduate students as a guest faculty in BSNV Post graduate college, University of Lucknow, India.
  2. Design practical courses in chemistry for undergraduate students and supervision to run their experiments and analyse the results.
  3. Private tutorials to undergraduate and higher secondary students in Oxford.
  4. I have some online teaching experience because I worked as an academic coach in India.
  5. Trained junior lab members in practical techniques to ensure competence and personal safety.
National & International Recognition
  1. 2008-2012: BBSRC UK postdoctoral fellowship, University of Oxford, Oxford, United Kingdom.
  2. 2012: Won the Agri-net Sandpit funding in collaboration with team of Imperial College London and Royal Holloway University UK.
  3. 2007-2008: Brain Korea-21 postdoctoral fellowship, Seoul National University, Seoul, South Korea.
  4. 2006-2007: Awarded Senior Research Fellow (SRF) by Council of Scientific and Industrial Research (CSIR), New Delhi, India.
  5. 2005: Best paper presentation awards in 9th International conferences of Indian Society of Chemist and Biologist.
  6. 2001-2005: Awarded Junior Research Fellow (JRF) by Central Drug Research Institute (CDRI), Lucknow, India.
  7. 2002: Qualified UPSLET (state level lectureship test) of University Grants Commission (UGC) New Delhi, India.
Professional Membership of Societies
  1. Member of Indian society of chemist and biologist CDRI, Lucknow (from 2001).
  2. Member of  Royal Society of Chemistry (MRSC, 2009)
Executive Summary

My research career has spanned for almost a decade (including PhD and post-doc), and has exposed me to the scientific culture in India, South Korea and United Kingdom. I got some managerial skills as was managing one of the group labs in University of Oxford. In Seoul National University South Korea and University of Oxford, United Kingdom, I have learnt the good points of their education system, which I think could be incorporated in the set-up of an interdisciplinary Indian institute like SNU. Having more than ten years of research and teaching experience in different areas of chemistry, gives me confidence that I can design new courses and conduct them successfully as per the requirements SNU. My post-doctoral experience at different institutions abroad has given me the confidence to perform interdisciplinary research at the highest level, which I am certain is a goal of SNU.

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