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SCHOOL OF NATURAL SCIENCES
NATURAL SCIENCES
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Faculty
Department of Life Sciences
Alok Bhattacharya
Distinguished Visiting Professor (Honorary),
Department of Life Sciences,
School of Natural Sciences
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Education Details
Ph.D. in Life Sciences from Jawaharlal Nehru University, New Delhi, 1973-1976
M.Sc. in Chemistry from Indian Institute of Technology, Kanpur, 1970-1972
Post-Doctoral Positions:
  • 1982-1985: Scientist, Tata Research Development & Design Centre (TCS), Pune, India,
  • 1981-1982: Senior Research Officer, Department of Biochemistry, A.I.I.M.S., New Delhi, India,
  • 1979-1981: Research Fellow, Department of Pathology, Harvard Medical School, Boston, USA,
  • 1977-1979: Visiting Fellow, Laboratory of Pathophysiology, National Cancer Institute, N.I.H., USA
Professional Experience:
  • 2004-2008: Dean, School of Information Technology, Jawaharlal Nehru University, New Delhi, India.
  • 2002-2004: Dean, School of Life Sciences, Jawaharlal, Nehru University, New Delhi, India.
  • 1998-2008: Co-ordinator Bioinformatics Centre, Jawaharlal Nehru University, New Delhi, India.
  • 2002 till date: Adjunct Faculty, School of Computational & Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.
  • 1993 till date: Professor, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
  • 1986-1993: Associate Professor, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
  • 1986: Guest Researcher, Laboratory of Parasitic Diseases, N.I.A.I.D., N.I.H., USA.
Research Interests:
Understanding biology of the protozoan parasite Entamoeba histolytica, MicroRNAs and cancer and Computation biology and bioinformatics

Recent Publications:
Jhingran A, Padmanabhan PK, Singh S, Anamika K, Bakre AA, Bhattacharya, S., Bhattacharya, A., Srinivasan, N. Madhubala R (2008) Characterization of the Entamoeba histolytica Ornithine Decarboxylase-Like Enzyme. PLoS Negl Trop Dis 2(1): e115. doi:10.1371/journal.pntd.0000115

Weber C, Blazquez S, Marion S, Ausseur C, Vats D, Krzeminski M, Rigothier S, Maroun RC, Bhattacharya, A., Guillen N. (2008) Bioinformatics and functional analysis of an Entamoeba histolytica mannosyltransferase necessary for parasite complement resistance and hepatical infection. PloS Negl. Trop. Dis. 2(2), e165 (Feb 13, 2008). doi/10.1371/journal.pntd.0000165

Jain, R., Santi-Rocca, J., Padhan, N., Bhattacharya, S., Guillen, N. & Bhattacharya, A. (2008) Calcium Binding Protein 1 of Entamoeba histolytica transiently associates with phagocytic cups in a calcium independent manner. Cell Microbiol. 10, 1373-1389.

Arya, R., Aslam, S., Gupta, S., Bora, RS., Vijayakrishnan, L., Gulati, P., Naithani, S, Mukherjee, S., Dastidar, S., Bhattacharya, A. and Saini, KS. (2008) Production and characterization of pharmacologically active recombinant human phosphodiesterase 4B in Dictyostelium discoideum. Biotechnology J., Jul;3(7):938-47.

Tyagi, S., Vaz, C., Gupta, V., Bhatia., R., Maheswari, S., Srinivasan, A., Bhattacharya, A. (2008) CID-miRNA: a web server for prediction of novel miRNA precursors in human genome. Biochem. Biophys. Res. Com., 372(4):831-4.
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Oswal, N., Sahni, N., Bhattacharya, A., Komath, S.S., Muthuswamy, R. (2008) Unique motifs identify PIG-A protein from glycosyltransferases of GT4 family. BMC Evol. Biol. Jun 4;8:168.

Vishnoi, A., Srivastava, A., Roy, R., Bhattacharya, A. (2008) MGDD: Mycobacterium tuberculosis genome diversity database. BMC Genomics 2008, 9:373doi:10.1186/1471-2164-9-373

Arya, R., Bhattacharya, A., Siani, KS (2008) Dictyostelium discoideum-a promising system for the production eukaryotic proteins. FASEB J. PMD: 187184070

Rout AK, Barnwal RP, Padhan N, Bhattacharya A, Chary KV (2008) Sequence specific 1H, 13C and 15N resonance assignments of a calmodulin-like calcium-binding protein from the protozoan parasite Entamoeba histolytica (EhCaM). Biomol. NMR Assign. Jun;2(1):77-9. Epub 2008 Apr 11

Mustafi SM, Mutalik RB, Jain R, Chandra K, Bhattacharya A., Chary KV. (2009) Structural characterization of a novel Ca2+-binding protein from Entamoeba histolytica: structural basis for the observed functional differences with its isoform. J. Biol. Inorg. Chem. 2009 Mar;14(3):471-83. Epub 2009 Jan 10

Jain R, Kumar S, Gourinath S, Bhattacharya S, Bhattacharya A. (2009) N- and C-terminal domains of the calcium binding protein EhCaBP1 of the parasite Entamoeba histolytica display distinct functions. PLoS ONE 2009;4(4):e5269. Epub 2009 Apr 22,

Panigrahi SK., Jhingan GD., Som I., Bhattacharya A., Petri WA Jr., Bhattacharya S. (2009) Promoter analysis of palindromic transcriptional units in the ribosomal DNA circle of Entamoeba histolytica. Euk. Cell 8, 69-76.

Nandi A., Vaz C., Bhattacharya A., Ramaswamy R. (2009) miRNA-regulated dynamics in circadian models. BMC Syst. Biol. May 5:3, 45.

Das S., Yennamali RM., Vishnoi A., Gupta P., Bhattacharya A. (2009) Single nucleotide variations associated with Mycobacterium tuberculosis KZN strains. J. Biosci. 34, 397-404.

Das S., Vishnoi A., Bhattacharya A. (2009) ABWGAT: Anchor based whole genome analysis tool. Bioinformatics Dec 15;25(24):3319-20. Epub 2009 Oct 14.

Jain R., Srimal S., Bhattacharya S., Bhattacharya A. (2009) Identification and Partial Characterization of a Dynamin-Like Protein, EhDLP1 from the protist parasite, Entamoeba histolytica. Euk. Cell Nov 13, 2009 (epub ahead of print) PMID: 19915078

Aggarwal S., Vaz C., Bhattacharya A., Srinivasan A. (2010) Prediction of novel precursor miRNAs using a context sensitive hidden Markov model (CSHMM). BMC Bioinformatics 11 (Suppl. 1): S29

Shrimal S., Bhattacharya S., Bhattacharya A. (2010) Serum-Dependent Selective Expression of EhTMKB1-95, a Member of Entamoeba histolytica B1 Family of Transmembrane Kinases. PLoS Pathogens 6(6), e1000929.

Vaz, C., Ahmad, H. M., Sharma, P., Gupta, R., Kumar, L., Kulshreshtha, R. and Bhattacharya, A. (2010). "Analysis of microRNA transcriptome by deep sequencing of small RNA libraries of peripheral blood." BMC Genomics 11(1): 288.

Vishnoi, A., Roy, R. Prasad HK. & Bhattacharya, A. (2010) An anchor-based whole genome phylogeny (ABWGP): A tool for inferring evolutionary relationship among closely related organisms. PLoS ONE 5(11): e14159.doi:10.1371/journal.pone.0014159.

Rout, AK, Padhan N, Barnwal, RP, Bhattacharya, A., Chary, KVR. (2011) Calmodulin-like protein of Entamoeba histolytica: Solution structure and calcium binding properties of partially folded protein. Biochem. 50, 181-193.

Somlata, Bhattacharya, S., Bhattacharya, A. (2011) A C2 domain protein kinase initiates phagocytosis in the protozoan parasite Entamoeba histolytica. Nat. Commun. 2, 230, doi: 10.1038/ncomms1199

Vaz C, Mer AS, Bhattacharya, A., Ramaswamy R, 2011 MicroRNAs Modulate the Dynamics of the NF-?B Signaling Pathway. PLoS ONE 6(11): e27774. doi:10.1371/journal.pone.0027774

Bharti R, Das R, Sharma P, Katoch K, Bhattacharya, A. (2011) MTCID: A database of genetic polymorphisms in clinical isolates of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2012 Mar;92(2):166-72. Epub 2011 Dec 29

Singh N, Ojha S, Bhattacharya, A., Bhattacharya S (2012) Establishment of a transient transfection system and expression of firefly luciferase in Entamoeba invadens. Mol Biochem Parasitol. 2012 Feb 1. [Epub ahead of print]

Das S, Duggal P, Roy R, Myneedu VP, Behera D, Prasad HK, Bhattacharya, A. (2012) Identification of Hot and Cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts. Sci Rep. 2012;2:297. Epub 2012 Mar 2. PubMed PMID: 22389766; PubMed Central PMCID: PMC3291883

Gupta AK, Panigrahi SK, Bhattacharya, A., Bhattacharya S. Self-circularizing 5'-ETS RNAs accumulate along with unprocessed pre ribosomal RNAs ingrowth-stressed Entamoeba histolytica. Sci Rep. 2012;2:303. Epub 2012 Mar 6.PubMed PMID: 22396851; PubMed Central PMCID: PMC3294279

Shrimal S, Saha A, Bhattacharya S, Bhattacharya, A. Lipids induce expression of serum-responsive transmembrane kinase EhTMKB1-9 in an early branching eukaryote Entamoeba histolytica. Sci Rep. 2012;2:333. Epub 2012 Mar 26. PubMed PMID:22451862; PubMed Central PMCID: PMC3312203

Yadav VP, Mandal PK, Bhattacharya, A., Bhattacharya S. Recombinant SINEs are formed at high frequency during induced retrotransposition in vivo. Nat Commun. 2012 May 22;3:854. doi: 10.1038/ncomms1855. PubMed PMID: 22617294.

Somlata, Sathisha K., Mridula Agrahari, Mrigya Babuta, Sudha Bhattachary and A Bhattacharya (2012) Autophosphorylation of Ser428 of EhC2PK plays a critical role in regulating erythrophagocytosis in the parasite Entamoeba histolytica J. Biol. Chem. Vol. 287, Issue 14, 10844-10852, March 30, 2012

Singh N, Ojha S, Bhattacharya, A., Bhattacharya S. Stable transfection and continuous expression of heterologous genes in Entamoeba invadens. Mol Biochem Parasitol. 2012 Jul;184(1):9-12. Epub 2012 Mar 7. PubMed PMID: 22426570.

Singh N, Ojha S, Bhattacharya A, Bhattacharya S. Establishment of a transient transfection system and expression of firefly luciferase in Entamoeba invadens. Mol Biochem Parasitol. 2012 May;183(1):90-3. Epub 2012 Feb 1. PubMed PMID: 22321531.

Gupta R, Dewan Esha, Bharti Richa, Bhattacharya, A (2012) Differential expression analysis of RNA seq data. ISRN Bioinformatics, Article ID 817508, 8 pages doi:10.5402/2012/817508

Aslam S, Bhattacharya S, Bhattacharya A. The Calmodulin-like Calcium Binding Protein EhCaBP3 of Entamoeba histolytica Regulates Phagocytosis and Is Involved in Actin Dynamics. PLoS Pathog. 2012 Dec;8(12):e1003055. doi: 10.1371/journal.ppat.1003055. Epub 2012 Dec 27. PubMed PMID: 23300437.

Abhyankar MM, Shrimal S, Gilchrist CA, Bhattacharya A, Petri WA Jr. The Entamoeba histolytica serum-inducible transmembrane kinase EhTMKB1-9 is involved in intestinal amebiasis. Int J Parasitol Drugs Drug Resist. 2012 Dec;2:243-248. PubMed PMID: 23267432; PubMed Central PMCID: PMC3528347.

Hon CC, Weber C, Sismeiro O, Proux C, Koutero M, Deloger M, Das S, Agrahari M,Dillies MA, Jagla B, Coppee JY, Bhattacharya A, Guillen N. Quantification of stochastic noise of splicing and polyadenylation in Entamoeba histolytica. Nucleic Acids Res. 2012 Dec 20. [Epub ahead of print] PubMed PMID: 23258700.

Das S, Roychowdhury T, Kumar P, Kumar A, Kalra P, Singh J, Singh S, Prasad H, Bhattacharya A. Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients. BMC Genomics. 2013 Jun 17;14:404. doi: 10.1186/1471-2164-14-404. PubMed PMID: 23773324; PubMed Central PMCID: PMC3699378.

Kaur D, Gupta AK, Kumari V, Sharma R, Bhattacharya A, Bhattacharya S. Computational prediction and validation of C/D, H/ACA and Eh_U3 snoRNAs of Entamoeba histolytica. BMC Genomics. 2012 Aug 14;13:390. doi: 10.1186/1471-2164-13-390. PubMed PMID: 22892049; PubMed Central PMCID:PMC3542256.

Kumari V, Iyer LR, Roy R, Bhargava V, Panda S, Paul J, Verweij JJ, Clark CG, Bhattacharya A, Bhattacharya S. Genomic distribution of SINEs in Entamoeba histolytica strains: implication for genotyping. BMC Genomics. 2013 Jul 1;14(1):432. [Epub ahead of print] PubMed PMID: 23815468.

B.M. Fredrik Pettersson, Ram G. Nitharwal, Sarbashis Das, Krishna P.R. Behra, Evgen Benedik, Uma T. Arasu, Nurul M. Islam, Santanu Dasgupta, Alok Bhattacharya & Leif A. Kirsebom (2013) Identification and expression of stressosomal proteins in Mycobacterium marinum under various growth and stress conditions. FEMS microbio. Let., 342 Issue: 2 Special Issue: SI Pages: 98-105 DOI: 10.1111/1574-6968.12118 Published: MAY 2013

Grewal JS, Padhan N, Aslam S, Bhattacharya A, Lohia A. The calcium binding protein EhCaBP6 is a microtubular-end binding protein in Entamoeba histolytica. Cell Microbiol. 2013 Jul 15. doi: 10.1111/cmi.12167. [Epub ahead of print] PubMed PMID: 23848346.

Rout AK, Patel S, Somlata, Shukla M, Saraswathi D, Bhattacharya A, Chary KV. Functional Manipulation of a Calcium-binding Protein from Entamoeba histolytica Guided by Paramagnetic NMR. J Biol Chem. 2013 Aug 9;288(32):23473-87. doi:10.1074/jbc.M112.411058. Epub 2013 Jun 19. PubMed PMID: 23782698.

Vaz C, Ahmad HM, Bharti R, Pandey P, Kumar L, Kulshreshtha R, Bhattacharya A. Analysis of the microRNA transcriptome and expression of different isomiRs in human peripheral blood mononuclear cells. BMC Res Notes. 2013 Sep 28;6(1):390. [Epub ahead of print] PubMed PMID: 24073671.

Roychowdhury T, Vishnoi A, Bhattacharya A. Next-Generation Anchor Based Phylogeny (NexABP): Constructing phylogeny from Next-generation sequencing data. Sci Rep. 2013 Sep 11;3:2634. doi: 10.1038/srep02634. PubMed PMID: 24022334; PubMed Central PMCID: PMC3769656.

Somlata, M. Babuta, S. Bhattacharya & A. Bhattacharya (2013) Protein kinases of parasitic protist Entamoeba histolytica in Protein phosphorylation in Parasites, Editors, C. Doerig, G. Spath & M. Weise. ISBN: 978-3-527-33235-9, Wiley-Blackwell, Germany

Katherine S. Ralston, Michael D. Solga, Nicole M. Mackey-Lawrence1, Somlata, Alok Bhattacharya & William A. Petri Jr (2014) trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion. Nature, doi:10.1038/nature13242, 508, 526-530.

Mansuri Shahid M, Bhattacharya S, Bhattacharya A (2014) A Novel Alpha Kinase EhAK1 Phosphorylates Actin and Regulates Phagocytosis in Entamoeba histolytica. PLoS Pathogens (in press)

Ahmad HM, Muiwo P, Ramachandran SS, Pandey P, Gupta YK, Kumar L, Kulshreshtha R, Bhattacharya A. (2014) miR-22 regulates expression of oncogenic neuro-epithelial transforming gene 1, NET1. FEBS J. 81(17):3904-19. doi:10.1111/febs.12926. Epub 2014 Jul 31. PubMed PMID: 25041463.

National & International Recognition:
  • National Science Talent Search Scholarship ( 1967-1976 )
  • Science Exhibition Award of Delhi University ( 1968, 1969 )
  • Robert McNamara Fellow of the World Bank ( 1985-1986 )
  • Rockefeller Biotechnology Career Development Award ( 1988-1990 )
  • Member Guha Research Conference (1992)
  • Shanti Swarup Bhatnagar Award (1994)
  • Fellow, Indian National Science Academy, New Delhi (2000)
  • J.C. Bose Fellowship of DST (2008)
  • Vice President, Indian National Science Academy, New Delhi (2011-2014)
Professional Affiliations:
  • Member, Research Council, CSIR-IHBT, Palampur
  • Member, Governing Body, CSIR
  • Member, Research Council CSIR-CMCSI, Bhavnagar
  • Member, USER committee Department of Science & Technology (DST)
  • Chairman, Task force on Bioinformatics, Computation Biology and Systems Biology, Dept of Biotechnology (DBT)
  • Member, Editorial Board of "Parasitology International" (Elsevier Science).
  • Member (term finished in 2007), Editorial Board "J. Bioscience" (Indian Science Academy, Bangalore)
  • Guest editor, Special Issue on "Genome Analysis", J. Bioscience, February 2002.
  • Guest Editor, Special Issue on "Bioinformatics: From Molecules to systems", J. Bioscience, August 2007.
  • Editorial Board member, International Journal of Integrative Biology
  • Associate Editor, PLoS Neglected Tropical Diseases
  • Editorial Board members, Scientific Reports (Nature)

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